1599476-85-3Relevant academic research and scientific papers
A Pd-based regioselective strategy to indole-1,2-fused 8- and 9-membered rings: Their evaluation as potential scaffolds for apoptosis in zebrafish
Prasad, Bagineni,Sreenivas, B. Yogi,Sushma, Araka,Yellanki, Swapna,Medisetti, Raghavender,Kulkarni, Pushkar,Pal, Manojit
supporting information, p. 2864 - 2868 (2014/05/06)
A strategy based on Pd-mediated ring closure of 1,2-disubstituted indoles containing an unactivated olefin leading to indole-1,2-fused 8- and 9-membered rings has been developed for the identification of new and potential scaffolds for apoptosis. A large number of fused indole derivatives containing an endocyclic double bond were synthesized using this robust methodology. A representative compound showed promising apoptotic properties in zebrafish embryos. This journal is the Partner Organisations 2014.
