1599477-66-3Relevant academic research and scientific papers
Efficient transformation of 7,14-dihydroxy-ent-kaurenes to novel ent-abietanes having cis-fused α-methylene γ-lactones under Mitsunobu reaction conditions and their cytotoxicities
Aoyagi, Yutaka,Ozawa, Kei,Kobayashi, Tatsuya,Hasuda, Tomoyo,Gui, Ming-Yu,Jin, Yong-Ri,Li, Xu-Wen,Fukaya, Haruhiko,Yano, Reiko,Hitotsuyanagi, Yukio,Takeya, Koichi
, p. 3030 - 3041 (2014/04/17)
Transformation of plant-origin 7,14-dihydroxy-ent-kaurenes to ent-abietanes having a cis-fused α-methylene γ-lactones was accomplished efficiently under the Mitsunobu reaction conditions. The yields of the desired products were apparently influenced by the steric hindrance at C-1. The cytotoxic activity on P388 murine leukemia cells of the ent-abietanes having cis-fused α-methylene γ-lactones produced were assayed.
