1599479-75-0Relevant academic research and scientific papers
Synthesis of fused benzimidazole-quinoxalinones via UDC strategy and following the intermolecular nucleophilic substitution reaction
Chen, Zhong-Zhu,Zhang, Jin,Tang, Dian-Yong,Xu, Zhi-Gang
, p. 2742 - 2744 (2014)
A series of fused benzimidazole-quinoxalinones were synthesized utilizing a one-pot UDC (Ugi/de-protection/cyclization) strategy to form a benzimidazole group with subsequent intermolecular nucleophilic substitution reaction to form quinoxalinone functionality. Using combinations of either a tethered ketone acid or aldehyde acid input the Ugi reaction was shown to afford (1) a ring system through lactamization, (2) a benzimidazole through de-protection and cyclization, and (3) a quinoxalinone through the nucleophilic substitution reaction. Scaffolds were produced in good yields and facile operation.
