1599484-91-9Relevant academic research and scientific papers
Asymmetric transfer hydrogenation of aromatic ketones catalyzed by new chiral C2-symmetric bis(sulfonyl) tetraaza ligands complexed with [Ru(η6-p-cymene)Cl2]2 in water
Liu, Xungao,Zhang, Tian,Hu, Yingying,Shen, Liang
, p. 1289 - 1295 (2014)
In this report, a new series of C2-symmetric bis(sulfonyl) tetraaza ligands were synthesized from (1S,2S)-1,2-diarylethylenediamine analogues and tested in the asymmetric transfer hydrogenation (ATH) of aromatic ketones by complexing with [Ru(η6-p-cymene)Cl2]2 employing sodium formate as hydrogen source in neat water. A moderate to excellent conversion (～99.8 %) and overall satisfying enantioselectivity (～92.8 %) were obtained with varied electronic and steric effects of the substituents on ligands and substrates.
Enantioselective Synthesis of (S)-Γ-Amino Alcohols by Ru/Rh/Ir Catalyzed Asymmetric Transfer Hydrogenation (ATH) with Tunable Chiral Tetraaza Ligands in Water
Chen, Jianxiang,Zhang, Tian,Liu, Xungao,Shen, Liang
, p. 601 - 609 (2019/01/14)
Abstract: (R/S)-γ-Amino alcohols are the key intermediates for the preparation of Fluoxetine, Atomoxetine, Nisoxetine and Duloxetine. In this paper, we describe an effective method to obtain (S)-γ-amino alcohols by Ru/Rh/Ir catalyzed asymmetric transfer h
