1599486-33-5

Basic information

• Product Name: Mal-PEG6-PFP
• Synonyms: Mal-PEG6-PFP
• CAS NO: 1599486-33-5
• Molecular Formula: C25H30F5NO10
• Molecular Weight: 599.498416
• Mol File: 1599486-33-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 623.0±55.0 °C(Predicted)
• Appearance: /
• Density: 1.353±0.06 g/cm3(Predicted)
• Solubility: Soluble in DMSO, DCM, DMF
• PKA: -2.34±0.20(Predicted)
• CAS DataBase Reference: Mal-PEG6-PFP(CAS DataBase Reference)
• NIST Chemistry Reference: Mal-PEG6-PFP(1599486-33-5)
• EPA Substance Registry System: Mal-PEG6-PFP(1599486-33-5)

Safety Data

• Hazardous Substances Data: 1599486-33-5(Hazardous Substances Data)

Usage

Description

Mal-PEG6-PFP is a PEG (polyethylene glycol) linker with maleimide and PFP (pentafluorophenyl) moieties. It is designed to facilitate the formation of stable covalent bonds with thiol and amine groups, respectively, under specific pH conditions. The hydrophilic PEG linker enhances the water solubility of a compound in aqueous environments, with the number of PEG units directly influencing the solubility properties.

Uses

Used in Bioconjugation:
Mal-PEG6-PFP is used as a bioconjugation agent for the selective and stable attachment of biomolecules, such as proteins or peptides, to other molecules or surfaces. The maleimide group reacts with thiol groups, while the PFP group forms stable amide bonds with amine groups, allowing for precise and efficient conjugation under mild conditions.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Mal-PEG6-PFP is used as a component in drug delivery systems to improve the solubility, stability, and bioavailability of therapeutic agents. The hydrophilic PEG linker can enhance the water solubility of hydrophobic drugs, while the reactive maleimide and PFP moieties allow for the covalent attachment of drugs to carriers or targeting ligands.
Used in Diagnostics:
Mal-PEG6-PFP can be employed in the development of diagnostic tools, such as imaging agents or biosensors, by enabling the stable and specific attachment of detection molecules to various platforms or surfaces. The thiol-reactive maleimide and amine-reactive PFP groups facilitate the conjugation of detection agents to the desired target, enhancing the sensitivity and specificity of the diagnostic tool.
Used in Material Science:
In the field of material science, Mal-PEG6-PFP can be utilized as a building block for the development of novel biocompatible materials with enhanced properties. The PEG linker can improve the hydrophilicity and biocompatibility of the material, while the reactive maleimide and PFP moieties allow for the incorporation of functional groups or biomolecules, tailoring the material's properties for specific applications.