1599529-58-4

Upstream product

• 1599529-49-3 6-bromo-2,4-dichloro-3-(4-(trifluoromethyl)benzyl)quinoline 
• 1599529-50-6 6-bromo-4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinoline 
• 1599529-75-5 N-methoxy-N, 1-dimethyl-1H-1,2,3-triazole-5-carboxamide 
• 1599529-78-8 4-chloro-6-iodo-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinoline 
• 1599529-57-3 (4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinoline-6-yl)(1-methyl-1H-1,2,3-triazol-5-yl)methanol 
• 1599529-77-7 2,4-dichloro-6-iodo-3-(4-(trifluoromethyl)benzyl)quinoline 
• 1599529-76-6 6-iodo-3-(4-(trifluoromethyl)benzyl)quinolin-2,4-diol 
• 1260760-00-6 6-iodoquinoline-2,4-diol 
• 923977-13-3 2,2-dimethyl-5-(4-trifluoromethyl-benzyl)-[1,3]dioxane-4,6-dione 
• 455-19-6 4-Trifluoromethylbenzaldehyde 

Downstream Products

• 1599531-50-6 6-((1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)(1-methyl-1H-1,2,3-triazol-5-yl)methyl)-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-4-carbonitrile 
• 1599531-49-3 C₂₇H₂₄ClF₃N₆O₂ 
• 1599531-48-2 C₂₇H₂₄ClF₃N₆O₂ 
• 1599531-51-7 C₂₈H₂₄F₃N₇O₂ 
• 1599531-52-8 C₂₈H₂₄F₃N₇O₂ 
• 1599531-47-1 (4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1,2-dimethyl-1H-imidazol-5-yl)(1-methyl-1H-1,2,3-triazol-5-yl)methanol 

Relevant academic research and scientific papers

ALKYL LINKED QUINOLINYL MODULATORS OF RORγt

The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.

ALKYL LINKED QUINOLINYL MODULATORS OF RORyt

The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.

METHYLENE LINKED QUINOLINYL MODULATORS OF RORyt

The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.