15997-24-7Relevant academic research and scientific papers
Enzymatic synthesis of 2-hydroxy-4H -quinolizin-4-one scaffolds by integrating coenzyme a ligases and a type III PKS from Huperzia serrata
Ding, Ning,Li, Jun,Liu, Xiao,Qi, Bowen,Shi, Shepo,Shi, Xiaoping,Tu, Pengfei,Wang, Juan,Wang, Xiaohui,Wu, Yun
, p. 23566 - 23572 (2020)
2-Hydroxy-4H-quinolizin-4-one scaffolds were enzymatically synthesized by integrating three enzymes including phenylacetate-CoA ligase (PcPCL) from an endophytic fungus Penicillium chrysogenum MT-12, malonyl-CoA synthase (AtMatB) from Arabidopsis thaliana, and a type III polyketide synthase (HsPKS3) from Chinese club moss Huperzia serrata. The findings paved the way to produce these kinds of structurally interesting alkaloids by engineered microorganisms. This journal is
Quinolizines and Indolizines, XIII. Acyl-2-hydroxy-4-quinolizinones
Kappe, Thomas,Linnau, Yendra
, p. 349 - 358 (2007/10/02)
The reaction of 2-picolylketones (1a, b) with reactive trichlorophenyl malonates (2a-f) leads to 1-acyl-2-hydroxy-4-quinolizinones (3a-i) which can be easily deacylated by boiling hydrochloric acid yielding 4-quinolizinones 4a-f.The 3-acetyl-2-hydroxy-4-quinolizinones 6 and 8 are obtained by Klosa-Ziegler acylation of 4a and 7, respectively.The reaction of the acetyl compound 3a with acetic anhydride yields the 2-pyrone derivative 9, whereas the propionyl derivative 3g yields the 4-pyrone 10 under the same conditions.Nitration of 3e does not give the 1-nitro derivative 12 but rather the 1,3-dinitro compound 11. - Keywords: 3-Acetyl-2-hydroxy-4-quinolizinones; 1-Acyl-2-hydroxy-4-quinolizinones; Bis-2,4,6-trichlorophenyl malonates; Deacylation; Klosa-Ziegler-acylation
