15997-24-7Relevant articles and documents
Enzymatic synthesis of 2-hydroxy-4H -quinolizin-4-one scaffolds by integrating coenzyme a ligases and a type III PKS from Huperzia serrata
Ding, Ning,Li, Jun,Liu, Xiao,Qi, Bowen,Shi, Shepo,Shi, Xiaoping,Tu, Pengfei,Wang, Juan,Wang, Xiaohui,Wu, Yun
, p. 23566 - 23572 (2020)
2-Hydroxy-4H-quinolizin-4-one scaffolds were enzymatically synthesized by integrating three enzymes including phenylacetate-CoA ligase (PcPCL) from an endophytic fungus Penicillium chrysogenum MT-12, malonyl-CoA synthase (AtMatB) from Arabidopsis thaliana, and a type III polyketide synthase (HsPKS3) from Chinese club moss Huperzia serrata. The findings paved the way to produce these kinds of structurally interesting alkaloids by engineered microorganisms. This journal is