15997-27-0

Basic information

• Product Name: 2-Hydroxy-4-oxo-3-phenyl-4H-chinolizin
• Synonyms: 2-Hydroxy-4-oxo-3-phenyl-4H-chinolizin
• CAS NO: 15997-27-0
• Molecular Weight: 237.258
• Mol File: 15997-27-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Hydroxy-4-oxo-3-phenyl-4H-chinolizin(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-4-oxo-3-phenyl-4H-chinolizin(15997-27-0)
• EPA Substance Registry System: 2-Hydroxy-4-oxo-3-phenyl-4H-chinolizin(15997-27-0)

Safety Data

• Hazardous Substances Data: 15997-27-0(Hazardous Substances Data)

Upstream product

• 2739-98-2 ethyl 2-(pyridinyl-2)acetate 
• 6303-73-7 1-(pyridin-2-yl)-butan-2-one 
• 6302-02-9 2-acetonylpyridine 
• 15781-73-4 di(2,4,6-trichlorophenyl)-2-phenylmalonate 
• 86796-16-9 1-Acetyl-2-hydroxy-3-phenyl-4-chinolizinon 
• 62-53-3 aniline 
• 86796-19-2 2-Hydroxy-3-phenyl-1-propionyl-4-chinolizinon 
• 129957-58-0 1-Ethoxycarbonyl-2-hydroxy-4-oxo-3-phenyl-4H-chinolizin 

Downstream Products

• 129957-72-8 6,7,8,9-Tetrahydro-2-hydroxy-4-oxo-3-phenyl-4H-chinolizin 
• 15997-28-1 7,9-diphenyl-pyrano[3,2-a;5,6-a']diquinolizine-6,10,16-trione 
• 39973-86-9 2-benzyl-1-hydroxy-5-phenyl-pyrano[3,2-a]quinolizine-3,6-dione 

Relevant articles and documents

Quinolizines and Indolizines, XIV. Rearrangement Reactions of Heterocycles, X. Ringtransformations of 1-Acyl-2-hydroxy-4-quinolizinones

By heating with ammonia or aniline 1-acyl-2-hydroxy-4-quinolizinones (1a-e) are transformed to 4-hydroxy-5-(2-pyridyl)-2-pyridones (3a-f), with 4a-d as minor sideproducts.The structure of the rearranged compound 3f was established by an independent synthe

Quinolizines and Indolizines, XIII. Acyl-2-hydroxy-4-quinolizinones

The reaction of 2-picolylketones (1a, b) with reactive trichlorophenyl malonates (2a-f) leads to 1-acyl-2-hydroxy-4-quinolizinones (3a-i) which can be easily deacylated by boiling hydrochloric acid yielding 4-quinolizinones 4a-f.The 3-acetyl-2-hydroxy-4-quinolizinones 6 and 8 are obtained by Klosa-Ziegler acylation of 4a and 7, respectively.The reaction of the acetyl compound 3a with acetic anhydride yields the 2-pyrone derivative 9, whereas the propionyl derivative 3g yields the 4-pyrone 10 under the same conditions.Nitration of 3e does not give the 1-nitro derivative 12 but rather the 1,3-dinitro compound 11. - Keywords: 3-Acetyl-2-hydroxy-4-quinolizinones; 1-Acyl-2-hydroxy-4-quinolizinones; Bis-2,4,6-trichlorophenyl malonates; Deacylation; Klosa-Ziegler-acylation