15997-82-7

Basic information

• Product Name: 4-(3,4-dihydro-2(1H)-isoquinolinyl)-1-(4-fluorophenyl)-1-butanone
• Synonyms: 4-(3,4-dihydro-2(1H)-isoquinolinyl)-1-(4-fluorophenyl)-1-butanone
• CAS NO: 15997-82-7
• Molecular Formula: C₁₉H₂₀FNO
• Molecular Weight: 297.3666032
• Mol File: 15997-82-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(3,4-dihydro-2(1H)-isoquinolinyl)-1-(4-fluorophenyl)-1-butanone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3,4-dihydro-2(1H)-isoquinolinyl)-1-(4-fluorophenyl)-1-butanone(15997-82-7)
• EPA Substance Registry System: 4-(3,4-dihydro-2(1H)-isoquinolinyl)-1-(4-fluorophenyl)-1-butanone(15997-82-7)

Safety Data

• Hazardous Substances Data: 15997-82-7(Hazardous Substances Data)

Upstream product

• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 3874-54-2 4-(4-fluorophenyl)-4-oxo-n-butyl chloride 

Relevant articles and documents

Design and synthesis of dual 5-HT1Aand 5-HT7receptor ligands

5-HT1Aand 5-HT7receptors have been at the center of discussions recently due in part to their major role in the etiology of major central nervous system diseases such as depression, sleep disorders, and schizophrenia. As part of our search to identify dual targeting ligands for these receptors, we have carried out a systematic modification of a selective 5HT7receptor ligand culminating in the identification of several dual 5-HT1Aand 5-HT7receptor ligands. Compound 16, a butyrophenone derivative of tetrahydroisoquinoline (THIQ), was identified as the most potent agent with low nanomolar binding affinities to both receptors. Interestingly, compound 16 also displayed moderate affinity to other clinically relevant dopamine receptors. Thus, it is anticipated that compound 16 may serve as a lead for further exploitation in our quest to identify new ligands with the potential to treat diseases of CNS origin.