15997-90-7Relevant articles and documents
ADAMTS INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF
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, (2022/01/24)
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Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors
Tsai, Ting-Yueh,Coumar, Mohane Selvaraj,Hsu, Tsu,Hsieh, Hsing-Pang,Chien, Chia-Hui,Chen, Chiung-Tong,Chang, Chung-Nien,Lo, Yu-Kang,Wu, Ssu-Hui,Huang, Chung-Yu,Huang, Yu-Wen,Wang, Min-Hsien,Wu, Hsin-Yi,Lee, Hong-Jen,Chen, Xin,Chao, Yu-Sheng,Jiaang, Weir-Torn
, p. 3268 - 3272 (2007/10/03)
A series of substituted pyrrolidine-2,4-dicarboxylic acid amides were synthesized as potential antidiabetic agents, and many of them showed good in vitro DPP-IV inhibition (IC50 = 2-250 nM) with selectivity over DPP-II, DPP8, and FAP enzymes. Selected compounds 8c and 11a showed in vivo plasma DPP-IV inhibition after oral administration in Wistar rats.