1600519-93-4

Upstream product

• 40928-13-0 4-chloroisatoic anhydride 
• 1073-69-4 N-4-chlorophenylhydrazine 

Downstream Products

• 1600520-06-6 6-chloro-1-(4-chlorophenyl)-2-phenylpyrazolo[5,1-b]quinazolin-9(1H)-one 
• 1600520-11-3 6-chloro-1-(4-chlorophenyl)-2-methylpyrazolo[5,1-b]quinazolin-9(1H)-one 

Relevant academic research and scientific papers

Substrate Controlled Synthesis of Benzisoxazole and Benzisothiazole Derivatives via PhI(OAc)2-Mediated Oxidation Followed by Intramolecular Oxidative O-N/S-N Bond Formation

A phenyliodine(III) diacetate (PIDA)-mediated, highly efficient and tandem approach for the synthesis of aryldiazenylisoxazolo(isothiazolo)arenes from simple 2-amino-N′-arylbenzohydrazides has been developed. The reaction proceeds via formation of (E)-(2-aminoaryl)(aryldiazenyl)methanone as the key intermediate, followed by intramolecular oxidative O-N/S-N bond formation in one pot at room temperature. The quiet different reactivity of the substrate is due to the formation of a diazo intermediate which encounters a nucleophilic attack by carbonyl oxygen on the electrophilic amine to produce isoxazole products, as compared to the previous reportsa,b,4 in which an N-acylnitrenium ion intermediate is intramolecularly trapped by an amine group.