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(3,3-dimethyl-morpholin-4-yl)-[5-(3-chloro-phenylethynyl)-pyrimidin-2-yl]-methanone is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1600527-96-5

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1600527-96-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1600527-96-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,0,0,5,2 and 7 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1600527-96:
(9*1)+(8*6)+(7*0)+(6*0)+(5*5)+(4*2)+(3*7)+(2*9)+(1*6)=135
135 % 10 = 5
So 1600527-96-5 is a valid CAS Registry Number.

1600527-96-5Downstream Products

1600527-96-5Relevant academic research and scientific papers

ETHYNYL DERIVATIVES AS MODULATORS OF MGLUR5 RECEPTOR ACTIVITY

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Page/Page column 15-16, (2014/05/07)

The present invention relates to ethynyl derivatives of formula (I) wherein Y is N or CH R1 is fluoro or chloro R2 is hydrogen or methyl or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. It has now surprisingly been found that the compounds of general formula I are metabotropic glutamate receptor antagonists (negative allosteric modulators) for use in the treatment of anxiety and pain, depression, Fragile-X syndrom, autism spectrum disorders, Parkinson's disease, and gastroesophageal reflux disease (GERD).

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