1600529-59-6Relevant academic research and scientific papers
Small molecule compound having an IDO1/TDO double target, preparation method and applications thereof
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Paragraph 0048; 0052; 0056-0058; 0308-0317, (2019/02/13)
The invention belongs to the field of chemical medicine, and particularly relates to a small molecule compound having an IDO1/TDO double target, wherein the general formula is defined in the specification. According to the present invention, the embodiment schemes prove that the small molecule compound can simultaneously inhibit two enzymes IDO1 and TDO so as to reduce the immune evasion of tumorcells, achieve self-cure of tumor diseases, achieve good medicinal potential and provides new potential choice for clinical medication; the preparation method has characteristics of simpleness, mild reaction condition, convenient operation, convenient control, low energy consumption, high yield and low cost, and is suitable for industrial production; and the prepared compound has advantages of high biological activity, strong selectivity to tumor cells, remarkable drug-like properties, and good application prospects in the pharmaceutical industry.
A mode of action study of cationic anthraquinone analogs: a new class of highly potent anticancer agents
Shrestha, Jaya P.,Subedi, Yagya Prasad,Chen, Liaohai,Chang, Cheng-Wei Tom
, p. 2012 - 2022 (2015/11/23)
Previously, we reported the synthesis and structure-activity relationship (SAR) study of a series of novel 4,9-dioxo-4,9-dihydro-1H-naphtho[2,3-d][1,2,3]triazol-3-ium salts, which had very potent anti-proliferative activities (low μM to nM GI50
Metal-free cycloaddition to synthesize naphtho[2,3-d][1,2,3]triazole-4,9-diones
Chen, Ping-Fan,Kuo, Kung-Kai,Vandavasi, Jaya Kishore,Boominathan, Siva Senthil Kumar,Chen, Chung-Yu,Wang, Jeh-Jeng
supporting information, p. 9261 - 9266 (2015/09/07)
A metal-free domino [3 + 2] cycloaddition is reported to construct naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives and provide an alternative approach to the azide-alkyne cycloadditions. The key features are easily available starting materials, mild reaction conditions, a good atom economy, eco-friendly characteristics and a broad substrate scope with high yields.
Synthesis and anticancer structure activity relationship investigation of cationic anthraquinone analogs
Shrestha, Jaya P.,Fosso, Marina Y.,Bearss, Jeremiah,Chang, Cheng-Wei Tom
, p. 96 - 102 (2014/04/03)
We have synthesized a series of novel 4,9-dioxo-4,9-dihydro-1H-naphtho[2,3- d][1,2,3]triazol-3-ium salts, which can be viewed as analogs of cationic anthraquinones. Unlike the similar analogs that we have reported previously, these compounds show relative
