1600529-87-0

Basic information

• Product Name: 4-(2-(2-naphthamido)-N-methylbenzamido)butanoic acid
• Synonyms: 4-(2-(2-naphthamido)-N-methylbenzamido)butanoic acid
• CAS NO: 1600529-87-0
• Molecular Weight: 390.439
• Mol File: 1600529-87-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-(2-naphthamido)-N-methylbenzamido)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-(2-naphthamido)-N-methylbenzamido)butanoic acid(1600529-87-0)
• EPA Substance Registry System: 4-(2-(2-naphthamido)-N-methylbenzamido)butanoic acid(1600529-87-0)

Safety Data

• Hazardous Substances Data: 1600529-87-0(Hazardous Substances Data)

Upstream product

• 1270974-10-1 4-(2-amino-N-methylbenzamido)butanoic acid 
• 2243-83-6 2-naphthaloyl chloride 
• 118-48-9 isatoic anhydride 
• 1119-48-8 4-(methylamino)butyric acid 

Relevant articles and documents

Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR)

Nuclear farnesoid X receptor (FXR) has important physiological roles in various metabolic pathways including bile acid, cholesterol and glucose homeostasis. The clinical use of known synthetic non-steroidal FXR ligands is restricted due to toxicity or poor bioavailability. Here we report the development, synthesis, in vitro activity and structure-activity relationship (SAR) of anthranilic acid derivatives as novel FXR ligands. Starting from a virtual screening hit we optimized the scaffold to a series of potent partial FXR agonists with appealing drug-like properties. The most potent derivative exhibited an EC50 value of 1.5 ± 0.2 μM and 37 ± 2% maximum relative FXR activation. We investigated its SAR regarding polar interactions with the receptor by generating derivatives and computational docking.