1600533-68-3Relevant academic research and scientific papers
Rhodium(I)-catalyzed decarbonylative spirocyclization through C=C bond cleavage of benzocyclobutenones: An efficient approach to functionalized spirocycles
Xu, Tao,Savage, Nikolas A.,Dong, Guangbin
supporting information, p. 1891 - 1895 (2014/03/21)
The rhodium-catalyzed formation of all-carbon spirocenters involves a decarbonylative coupling of trisubstituted cyclic olefins and benzocyclobutenones through C=C activation. The metal-ligand combination [{Rh(CO)2Cl}2]/P(C6F5)3 catalyzed this transformation most efficiently. A range of diverse spirocycles were synthesized in good to excellent yields and many sensitive functional groups were tolerated. A mechanistic study supports a hydrogen-transfer process that occurs through a β-H elimination/decarbonylation pathway. All-carbon spirocenters were formed by a decarbonylative coupling of trisubstituted cyclic olefins and benzocyclobutenones through C=C activation. The metal-ligand combination of [{Rh(CO)2Cl}2] and P(C6F 5)3 catalyzed this transformation most efficiently; a range of spirocyclic rings was thus synthesized in good to excellent yields. Copyright
