16006-62-5

Usage

Uses

Used in Pharmaceutical Industry:
6-ethyl-9-pentofuranosyl-9H-purine is used as a pharmaceutical compound for its potential anticancer properties. It may target various types of cancer by modulating signaling pathways and exhibiting synergistic effects when combined with conventional chemotherapeutic drugs, enhancing chemo-sensitivity and efficacy in resistant cases.
6-ethyl-9-pentofuranosyl-9H-purine is also used as an antiviral agent, leveraging its purine derivative nature to inhibit viral replication and reduce the spread of infections.
Furthermore, it is used as an anti-inflammatory agent, potentially reducing inflammation and alleviating symptoms associated with various inflammatory conditions.
In Drug Development:
6-ethyl-9-pentofuranosyl-9H-purine is utilized in the development of new drugs and therapies, given its diverse biological activities and potential to target a range of diseases and conditions. Understanding its specific properties and mechanisms of action can contribute to the advancement of medical treatments and improve patient outcomes.

Upstream product

• 5987-73-5 2',3',5'-O-triacetyl-6-chloroinosine 
• 52921-38-7 (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-ethyl-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate 
• 84765-96-8 6-chloro-9-(2,3,5-tris-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl)-9H-purine 
• 66782-10-3 tri-O-benzoyl-1-(6-methylsulfanyl-purin-9-yl)-β-D-1-deoxy-ribofuranose 
• 69359-23-5 6-(α-ethoxycarbonyl)ethyl-9-β-D-ribofuranosylpurine 
• 6741-90-8 2',3',5'-tri-O-benzoyl-6-thioinosine 
• 69359-21-3 6-ethoxycarbonylmethyl-9-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-purine 
• 69471-43-8 6-bis(ethoxycarbonyl)methyl-9-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-purine 
• 69359-20-2 6-methylsulfonyl-9-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-purine 

Relevant academic research and scientific papers

Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: Palladium mediated cross-coupling of organozinc halides with 6-chloropurine nucleosides [1]

A series of C-6 alkyl, cycloalkyl, and aryl-9-(β-d-ribofuranosyl) purines were synthesized and their substrate activities with Escherichia coli purine nucleoside phosphorylase (E. coli PNP) were evaluated. (Ph 3P)4Pd-mediated cross-c

SYNTHESIS OF 6-ALKYL AND 6-ARYL SUBSTITUTED 9-β-D-RIBOFURANOSYL PURINES VIA THE NICKEL CATALYZED COUPLING OF GRIGNARD REAGENTS TO 2',3',5'-Tris-O-(t-BUTYLDIMETHYLSILYL)-9-β-D-RIBOFURANOSYL-6-CHLOROPURINE

A series of 6-substituted purine nucleosides have been synthesized in moderate yield by the nickel catalyzed cross coupling reaction between alkyl- and aryl-Grignard reagents and 2',3',5'-tris-O-(t-butyldimethylsilyl)-9-β-D-ribofuranosyl-6-chloropurine.

Reaction of 6-Methylsulfonylpurine Riboside with Carbon Nucleophiles and the Synthesis of 6-Alkylpurine Nucleosides. (Nucleosides and Nucleotides. XXIX)

Treatment of 6-methylsulfonyl-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine with ethyl acetoacetate and sodium hydride in tetrahydrofuran afforded, after deblocking, 6-ethoxycarbonylmethyl-9-β-D-ribofuranosylpurine.Similarly, replacement of the 6-methylsulfonyl moiety with other carbanions derived from diethyl malonate, ethyl cyanoacetate, malononitrile, nitromethane, and sodium cyanide gave the corresponding 6-C-substituted purine nucleosides.Most of these derivatives exist as the 6-(1H)-exomethylene tautomeric forms. 6-Ethoxycarbonylmethylpurine riboside was further converted to 6-methyl, ethyl, propyl, butyl, and pentyl-purine ribosides by decarboxylation or prior alkylation of the methylene group followed by de-carboxylation.This reaction sequence facilitated the preparation of hitherto almost inaccessible alkyl or C-substituted purine nucleosides.Keywords- nucleophilic aromatic substitution; carbon nucleophiles; purine nucleosides; UV; NMR; tautomerism