16006-62-5

Basic information

• Product Name: 6-ethyl-9-pentofuranosyl-9H-purine
• CAS NO: 16006-62-5
• Molecular Formula: C₁₂H₁₆N₄O₄
• Molecular Weight: 280.2798
• Mol File: 16006-62-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 585.2°C at 760 mmHg
• Flash Point: 307.7°C
• Density: 1.72g/cm³
• Vapor Pressure: 1.55E-14mmHg at 25°C
• Refractive Index: 1.761
• CAS DataBase Reference: 6-ethyl-9-pentofuranosyl-9H-purine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-ethyl-9-pentofuranosyl-9H-purine(16006-62-5)
• EPA Substance Registry System: 6-ethyl-9-pentofuranosyl-9H-purine(16006-62-5)

Safety Data

• Hazardous Substances Data: 16006-62-5(Hazardous Substances Data)

Usage

General Description

The chemical compound "6-ethyl-9-pentofuranosyl-9H-purine" is a purine derivative with an ethyl group attached to the sixth carbon atom and a pentofuranosyl group attached to the ninth carbon atom. It belongs to the class of nucleosides, which are important components of DNA and RNA. Nucleosides play crucial roles in the storage and transfer of genetic information within living organisms. "6-ethyl-9-pentofuranosyl-9H-purine" may have potential applications in pharmaceuticals, as purine derivatives are known for their diverse biological activities, including anticancer, antiviral, and anti-inflammatory properties. Understanding the specific properties and potential uses of this compound could lead to the development of new drugs and therapies.

Upstream product

• 52921-38-7 (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-ethyl-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate 
• 5987-73-5 2',3',5'-O-triacetyl-6-chloroinosine 
• 84765-96-8 6-chloro-9-(2,3,5-tris-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl)-9H-purine 
• 6741-90-8 2',3',5'-tri-O-benzoyl-6-thioinosine 
• 69359-21-3 6-ethoxycarbonylmethyl-9-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-purine 
• 69471-43-8 6-bis(ethoxycarbonyl)methyl-9-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-purine 
• 69359-20-2 6-methylsulfonyl-9-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-purine 
• 66782-10-3 tri-O-benzoyl-1-(6-methylsulfanyl-purin-9-yl)-β-D-1-deoxy-ribofuranose 
• 69359-23-5 6-(α-ethoxycarbonyl)ethyl-9-β-D-ribofuranosylpurine 

Relevant articles and documents

Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: Palladium mediated cross-coupling of organozinc halides with 6-chloropurine nucleosides [1]

A series of C-6 alkyl, cycloalkyl, and aryl-9-(β-d-ribofuranosyl) purines were synthesized and their substrate activities with Escherichia coli purine nucleoside phosphorylase (E. coli PNP) were evaluated. (Ph 3P)4Pd-mediated cross-c

Reaction of 6-Methylsulfonylpurine Riboside with Carbon Nucleophiles and the Synthesis of 6-Alkylpurine Nucleosides. (Nucleosides and Nucleotides. XXIX)

Treatment of 6-methylsulfonyl-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine with ethyl acetoacetate and sodium hydride in tetrahydrofuran afforded, after deblocking, 6-ethoxycarbonylmethyl-9-β-D-ribofuranosylpurine.Similarly, replacement of the 6-methylsulfonyl moiety with other carbanions derived from diethyl malonate, ethyl cyanoacetate, malononitrile, nitromethane, and sodium cyanide gave the corresponding 6-C-substituted purine nucleosides.Most of these derivatives exist as the 6-(1H)-exomethylene tautomeric forms. 6-Ethoxycarbonylmethylpurine riboside was further converted to 6-methyl, ethyl, propyl, butyl, and pentyl-purine ribosides by decarboxylation or prior alkylation of the methylene group followed by de-carboxylation.This reaction sequence facilitated the preparation of hitherto almost inaccessible alkyl or C-substituted purine nucleosides.Keywords- nucleophilic aromatic substitution; carbon nucleophiles; purine nucleosides; UV; NMR; tautomerism