160069-74-9

Basic information

• Product Name: [(R)-1-(4,4,6,6-Tetramethyl-[1,3]dioxan-2-yl)-propyl]-carbamic acid benzyl ester
• CAS NO: 160069-74-9
• Molecular Weight: 335.444
• Mol File: 160069-74-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(R)-1-(4,4,6,6-Tetramethyl-[1,3]dioxan-2-yl)-propyl]-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(R)-1-(4,4,6,6-Tetramethyl-[1,3]dioxan-2-yl)-propyl]-carbamic acid benzyl ester(160069-74-9)
• EPA Substance Registry System: [(R)-1-(4,4,6,6-Tetramethyl-[1,3]dioxan-2-yl)-propyl]-carbamic acid benzyl ester(160069-74-9)

Safety Data

• Hazardous Substances Data: 160069-74-9(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 160069-68-1 (R)-2-Phenyl-2-[(R)-1-(4,4,6,6-tetramethyl-[1,3]dioxan-2-yl)-propylamino]-ethanol 

Downstream Products

• 143915-15-5 (R)-1-oxobutane-2-benzylcarbamate 

Relevant articles and documents

Enantioselective synthesis of α-amino acetals (aldehydes) via nucleophilic 1,2-addition to chiral 1,3-oxazolidines

A general procedure for the diastereoselective addition of Grignard reagents to chiral 2-(4,4,6,6-tetramethyl-1,3-dioxan-2-yl)-4-substituted-1,3-oxazolidines 4 is described. Chemical yields and diastereoselectivities are generally excellent (91-100% de). The resulting amino alcohols 6 may be oxidatively or reductively cleaved to enantiomerically enriched α-amino acetals 3 which are useful chiral building blocks.