160072-66-2Relevant articles and documents
Synthesis of Branched Triubiquitin Active-Site Directed Probes
Liu, Jiaan,Li, Yanfeng,Deol, Kirandeep K.,Strieter, Eric R.
, p. 6790 - 6794 (2019)
Active-site directed probes are powerful tools for studying the ubiquitin conjugation and deconjugation machinery. Branched ubiquitin chains have emerged as important proteasome-targeting signals for aggregation-prone proteins and cell cycle regulators. By implementing a new synthetic strategy for the electrophilic warhead, we herein report on the generation and reactivity of a series of branched triubiquitin active-site directed probes. These new tools can be used to dissect the molecular basis of branched chain assembly and disassembly.