160081-15-2Relevant academic research and scientific papers
FLUOROOLEFIN PEPTIDE ISOSTERES - TOOLS FOR CONTROLLING PEPTIDE CONFORMATIONS
Boros, Livia G.,Corte, Bart De,Gimi, Rayomand H.,Welch, John T.,Wu, Yang,Handschumacher, Robert E.
, p. 6033 - 6036 (2007/10/02)
Fluoroolefin dipeptide isosteres were synthesized applying the Peterson reaction as a novel method for fluoroolefination.The dipeptide isosteres were elaborated to provide the conformationally constrained analogs (1-(R), 1-(S) and 2-(R), 2-(S)) of the Suc-Ala-Gly-Pro-Phe-pNA tetrapeptide, a synthetic substrate of cyclophilin.
