160088-01-7Relevant academic research and scientific papers
Synthesis of (R)-N-[4-[4-(dibutylamino)-1-hydroxybutyl]phenyl]methanesulfonamide, (E)-2-butenedioate (2:1) salt (artilide fumarate) and the enantiomers of N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide, (E)-2-butenedioate (2:1) salt (ibutilide fumarate)
Perricone, Sam C.,Chidester, Constance G.,Hester, Jackson B.
, p. 677 - 690 (2007/10/03)
Syntheses of artilide fumarate, its (S) enantiomer and the (R) and (S) enantiomers of ibutilide fumarate were achieved by reduction of the prochiral ketones with (+) and (-)-B-chlorodiisopinocampheylborane. Several methods for analyzing the optical purity of these compounds are presented. The absolute configurations were established by a single crystal X-ray crystallographic analysis of (S)-N-[4-[4-(dibutylamino)-1-hydroxy-4-oxobutyl]phenyl]methanesulfonamide. Copyright
Synthesis of radiolabeled racemic and enantiomeric antiarrhythmic agents
Stolle,Stelzer,Hester,Perricone,Hsi
, p. 929 - 942 (2007/10/02)
Ibutilide fumarate, racemic N-[4-[4-(ethyl-n-heptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide hemifumarate, and artilide, the R-(+)-enantiomer of N-[4-[4-(di-n-butylalmino)-1-hydroxybutyl]-phenyl]methanesulfonamide hemifumerate, are under clinical in
