160098-96-4

Basic information

• Product Name: SCH 58261
• Synonyms: 7H-Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, 2-(2-furanyl)-7-(2-phenylethyl)-;2-(Furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyriMidin-5-aMine
• CAS NO: 160098-96-4
• Molecular Formula: C₁₈H₁₅N₇O
• Molecular Weight: 345.365
• Product Categories: Adenosine receptor
• Mol File: 160098-96-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 223 °C
• Appearance: off-white/solid
• Density: 1.54g/cm³
• Refractive Index: 1.807
• Storage Temp.: Store at RT
• Solubility: DMSO: >10 mg/mL, soluble
• PKA: 2.78±0.30(Predicted)
• CAS DataBase Reference: SCH 58261(CAS DataBase Reference)
• NIST Chemistry Reference: SCH 58261(160098-96-4)
• EPA Substance Registry System: SCH 58261(160098-96-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 160098-96-4(Hazardous Substances Data)

Usage

Uses

SCH 58261 is a potent and selective A2A adenosine receptor antagonist.

Biological Activity

Potent and selective A 2A adenosine receptor competitive antagonist (K i = 1.3 nM). Displays 323-, 53- and 100-fold selectivity over A 1 , A 2B and A 3 receptors, respectively.

Biochem/physiol Actions

SCH 58261 reduces the levels of TNF-α, Fas-L, Bax expression and activation of JNK-MAPK pathway. It has neuroprotective effects as it reduces demyelination of the neurons. SCH 58261 increases the concentration of secretion of dopamine and elicits locomotor sensitization, an attractive option in the possible treatment of Parkinson′s disease.

InChI:InChI=1/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)

Upstream product

• 162401-28-7 Furan-2-carboxylic acid (4-imino-1-phenethyl-1,4-dihydro-pyrazolo[3,4-d]pyrimidin-5-yl)-amide 
• 159979-88-1 7-(β-phenylethyl)-2-(2-furyl)pyrazolo<4,3-e>-1,2,4-triazolo<1,5-c>pyrimidine 
• 159979-74-5 5-amino-4-cyano-1-(β-phenylethyl)pyrazole 
• 3326-71-4 2-furoic acid hydrazide 

Downstream Products

• 396124-33-7 4-[2-(5-amino-2-furan-2-ylpyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl]benzenesulfonyl chloride 

Relevant articles and documents

Adenosine A3 receptor modulators

The compounds of the following formula: wherein R, R2, R3 and A have the meanings given in the specification, are endowed with selective A3 adenosine receptor antagonist activity. These compounds can be used in a pharmaceu

Adenosine A3 receptor modulators

The compounds of the following formula: wherein R, R1, R2R3and A have the meanings given in the specification, are endowed with selective A3adenosine receptor agonist activity. These compounds can be used in a p