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Usage

Uses

Used in Environmental Analysis:
L-BMAA HYDROCHLORIDE is used as a standard for the analysis of BMAA isomers in desert crust material. This application helps researchers understand the distribution and concentration of BMAA in the environment, which can have implications for human and animal health.
Used in Biological Research:
L-BMAA HYDROCHLORIDE is used as an additive in the f/2+Si medium to treat the cells of Phaeodactylum tricornutum and Thalassiosira weissflogii. This application allows scientists to study the effects of BMAA on these marine microalgae, which can provide insights into the toxin's impact on marine ecosystems and the organisms that inhabit them.

Biochem/physiol Actions

L-BMAA hydrochloride helps to block the addition of heparan sulfate to glypican-1. It possesses unusual glutamate receptor binding properties. It may cause amyotrophic lateral sclerosis/Lou Gehrig′s disease.

Upstream product

• 593-51-1 methylamine hydrochloride 

Relevant academic research and scientific papers

A simple and efficient approach to the synthesis of β-N-methylamino-l- alanine (BMAA)

A novel, efficient, and straightforward synthesis of β-N-methylamino- l-alanine (BMAA) in two steps starting from l-N,N-dibenzylserine benzyl ester is described. This method, in the light of other syntheses of BMAA, provides benefits such as mild reaction conditions, a simple work-up procedure, good yields, and the retention of the serine stereochemistry.

Synthesis of novel chiral NiII complexes of dehydroalanine Schiff bases and their reactivity in asymmetric nucleophilic addition reactions. Novel synthesis of (S)-2-carboxypiperazine

New chiral NiII complexes of Schiff bases of dehydroalanine with modified chiral auxiliaries (S)-2-N-[N′-(3,4-dichlorobenzyl)prolyl] aminobenzophenone (3,4-DCBPB), (S)-2-N-[N′-(3,4-dimethylbenzyl)prolyl] aminobenzophenone (3,4-DMBPB), (S)-2-N-[N′-(2-chlorobenzyl)prolyl] aminobenzophenone (2-CBPB), and (S)-2-N-[N′-(2-fluorobenzyl)prolyl]- aminobenzophenone (2-FBPB) have been synthesized. Asymmetric Michael addition reactions of primary and secondary amines and thiols to the dehydroalanine moieties of the complexes were studied. (S)-2-FBPB was found to be the best chiral auxiliary in terms of both selectivity of the reactions (de ～92-96%) and reactivity of the complexes. A novel synthetic route toward (S)-2-carboxypiperazine was developed based on the auxiliary.