160129-44-2

Upstream product

• 95458-77-8 oxazolyl chloride 
• 160129-43-1 6-(2-methylbenzoylamino)nicotinic acid 
• 201686-62-6 6-[bis-(2-methyl-benzoyl)-amino]-nicotinic acid ethyl ester 
• 39658-41-8 ethyl-6-amino-nicotinate 

Relevant academic research and scientific papers

5-Fluoro-2-methyl-N-[5-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-yl carbonyl)-2-pyridinyl]benzamide (CL-385004) and analogs as orally active arginine vasopressin receptor antagonists

Synthesis and structure-activity relationships (SAR) of orally active arginine vasopressin (AVP) receptor antagonists are discussed. Potent and orally active AVP receptor antagonists are produced when ring A of VPA-985 (1) is replaced with a 3-pyridinyl unit (2b).

Benzoazepinyl compounds as oxytocin and vasopressin antagonists

Novel benzoheterocyclic compound of the formula (1): STR1 and pharmaceutically acceptable salts thereof, which show excellent anti-vasopressin activity and oxytocin antagonistic activity, and are useful as a vasopressin antagonist or oxytocin antagonist.