160133-75-5

Basic information

• Product Name: METHYL 3-AMINO-4-(4-METHYLPHENYL)-THIOPHENE-2-CARBOXYLATE
• Synonyms: METHYL 3-AMINO-4-P-TOLYLTHIOPHENE-2-CARBOXYLATE;METHYL 3-AMINO-4-(4-METHYLPHENYL)-THIOPHENE-2-CARBOXYLATE
• CAS NO: 160133-75-5
• Molecular Formula: C₁₃H₁₃NO₂S
• Molecular Weight: 247.31
• Mol File: 160133-75-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL 3-AMINO-4-(4-METHYLPHENYL)-THIOPHENE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-AMINO-4-(4-METHYLPHENYL)-THIOPHENE-2-CARBOXYLATE(160133-75-5)
• EPA Substance Registry System: METHYL 3-AMINO-4-(4-METHYLPHENYL)-THIOPHENE-2-CARBOXYLATE(160133-75-5)

Safety Data

• Hazardous Substances Data: 160133-75-5(Hazardous Substances Data)

Upstream product

• 72899-87-7 2-(p-methylphenyl)-3-hydroxyacrylonitrile 
• 63726-65-8 α-formyl-4-methylbenzeneacetonitrile 
• 2947-61-7 (4-methylphenyl)acetonitrile 
• 2365-48-2 Methyl thioglycolate 

Downstream Products

• 160139-87-7 7-phenylthieno<3,2-d>pyrimidine-2,4-dione 
• 160139-88-8 7-(4-methylphenyl)thieno<3,2-d>pyrimidine-2,4-dione 
• 1621967-66-5 3-(4-methoxyphenyl)-7-(p-tolyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 1026608-51-4 Acetic acid 2-(2,4-dioxo-7-p-tolyl-3,4-dihydro-2H-thieno[3,2-d]pyrimidin-1-ylmethoxy)-ethyl ester 
• 1026644-82-5 Acetic acid 2-(2,4-dioxo-7-phenyl-3,4-dihydro-2H-thieno[3,2-d]pyrimidin-1-ylmethoxy)-ethyl ester 
• 1026286-98-5 7-p-Tolyl-2,4-bis-trimethylsilanyloxy-thieno[3,2-d]pyrimidine 
• 1026185-30-7 7-Phenyl-2,4-bis-trimethylsilanyloxy-thieno[3,2-d]pyrimidine 

Relevant articles and documents

Synthesis and biological evaluation of N3-alkyl-thienopyrimidin-4-ones as mGluR1 antagonists

Metabotropic glutamate receptor subtype 1 (mGluR1) is a potential target for the treatment of neuropathic pain, and there has been much effort to discover mGluR1 antagonists. In this study, a series of N3-alkyl-thienopyrimidin-4-ones were prepared by introducing various alkyl and aryl groups to the N3- and 7-positions of the thienopyrimidin-4-one core structure, respectively, and their inhibitory activities against mGluR1 were biologically evaluated. Structure-activity relationship study revealed that the trans-4-methylcyclohexyl, cycloheptyl, and cyclooctyl groups at N3-position, and 2-fluorophenyl group at 7-position were most effective in potentiating the inhibitory activity of the thienopyrimidin-4-one derivatives against mGluR1. Among the synthesized compounds, 3-cyclooctyl-7-phenylthienopyrimidin-4-one and 3-cycloheptyl-7-(2-fluorophenyl)thienopyrimidin-4-one exhibited the most potent inhibitory activities with IC50 values of 115 and 107 nM, respectively.

Synthesis of thieno[3,2-d]pyrimidine-2,4-diones cyclic and acyclic nucleosides as potential anti HIV agents

Synthesis of cyclic and acyclic nucleosides was achieved by alkylation of 7-methyl or arylthieno[3,2-d]pyrimidine-2,4-diones following the Vorbruggen and Niedballa's method [1]. After a possible deprotection, potential anti HIV agents were obtained.