160140-64-7

Upstream product

• 1039170-80-3 C₂₂H₂₀N₂O₂S 
• 51608-60-7 N-(benzylidene)-p-methylbenzenesulfonamide 
• 3419-91-8 N-(2-pyridyl)indole 
• 82414-26-4 (1H-indol-2-yl)phenylmethanone oxime 

Downstream Products

• 1027975-83-2 ((1S,2S,4R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-{[(1H-indol-2-yl)-phenyl-methyl]-carbamoyl}-5-phenyl-pentyl)-carbamic acid tert-butyl ester 
• 1026657-06-6 (2R,4S,5S)-5-Amino-2-benzyl-4-hydroxy-6-phenyl-hexanoic acid [(1H-indol-2-yl)-phenyl-methyl]-amide 

Relevant academic research and scientific papers

Sustainable Manganese-Catalyzed C?H Activation/Hydroarylation of Imines

Expedient C?H additions of heteroarenes onto aldimines were realized by a sustainable manganese catalysis manifold within a removable directing group strategy. The C?H activation features most user-friendly reaction conditions, excellent chemo- and position-selectivity as well as ample substrate scope. Detailed experimental mechanistic studies suggest an organometallic C?H manganesation mode of action.

Crystal-structure-based design and synthesis of novel C-terminal inhibitors of HIV protease

The X-ray crystal-structure-based design, synthesis, computational evaluation, and activity of a novel class of HIV protease inhibitors are described. The initial lead compounds 2 and 3 were designed by modeling replacement groups for the C-terminal Val-V