1601403-17-1

Basic information

• Product Name: N-(3-(4-methylpiperazin-1-yl)phenyl)-3-oxobenzo[d]isothiazole-2(3H)-carboxamide
• Synonyms: N-(3-(4-methylpiperazin-1-yl)phenyl)-3-oxobenzo[d]isothiazole-2(3H)-carboxamide
• CAS NO: 1601403-17-1
• Molecular Weight: 368.459
• Mol File: 1601403-17-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-(4-methylpiperazin-1-yl)phenyl)-3-oxobenzo[d]isothiazole-2(3H)-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-(4-methylpiperazin-1-yl)phenyl)-3-oxobenzo[d]isothiazole-2(3H)-carboxamide(1601403-17-1)
• EPA Substance Registry System: N-(3-(4-methylpiperazin-1-yl)phenyl)-3-oxobenzo[d]isothiazole-2(3H)-carboxamide(1601403-17-1)

Safety Data

• Hazardous Substances Data: 1601403-17-1(Hazardous Substances Data)

Upstream product

• 148546-99-0 3-(4-methylpiperazin-1-yl)aniline 
• 2634-33-5 1,2-benzisothiazolin-3-one 

Relevant articles and documents

1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors

A novel series of 1,2-benzisothiazol-3-one derivatives was synthesized and their biological activities were evaluated for inhibiting caspase-3 and -7 activities, in which some of them showed low nanomolar potency against caspase-3 in vitro and significant protection against apoptosis in a camptothecin-induced Jurkat T cells system. Among the tested compounds, compound 5i exhibited the most potent caspase-3 inhibitory activity (IC50 = 1.15 nM). The molecular docking predicted the interactions and binding modes of the synthesized inhibitor in the caspase-3 active site.