1601449-67-5Relevant academic research and scientific papers
Palladium-catalyzed direct arylation of polyfluoroarene and facile synthesis of liquid crystal compounds
Ma, Xiaowei,Liu, Yan,Liu, Ping,Xie, Jianwei,Dai, Bin,Liu, Zhiyong
, p. 180 - 185 (2014)
A convenient approach has been developed to prepare polyfluorobiphenyl by Pd(OAc)2/PCy3-catalyzed direct arylation of polyfluoroarenes with aromatic halides in the presence of Cs2CO 3 as base and toluene as solvent. In most cases, the desired arylated products of aromatic bromides were obtained in good to excellent yield at 80°C, and aryl chlorides also gave modest to good yields of arylated products at 110°C. According to this efficient C - C bondforming method, polyfluorobiphenyl liquid crystal compounds were prepared by Pd-catalyzed direct arylation reactions of polyfluoroarenes with long alkyl chain substituted aryl bromides in 62-96% yield. Copyright
