1601461-41-9Relevant academic research and scientific papers
Convenient synthesis of enantiopure (R-) and (S-)-3-fluoro-3- aminomethylpyrrolidines
Yarmolchuk, Vladimir S.,Mykhalchuk, Vladimir L.,Mykhailiuk, Pavel K.
, p. 3011 - 3017 (2014/04/17)
(R-)- and (S-)-3-fluoro-3-aminomethylpyrrolidines were synthesized from methyl α-fluoroacrylate in eight steps. α-Phenylethylamine was used as a chiral auxiliary to separate the racemic mixture. The overall synthesis yield was 31%.
