16015-70-6

Usage

Uses

Used in Pharmaceutical Research:
1-(3-Methoxyphenyl)piperazine hydrochloride is used as a research chemical for studying serotonin receptors and neurotransmitters, which play a crucial role in mood regulation and various neurological functions.
Used in Therapeutic Applications:
1-(3-Methoxyphenyl)piperazine hydrochloride is used as a potential therapeutic agent for treating conditions such as depression, anxiety, and other mood disorders, due to its interaction with serotonin receptors.
Used in Pharmaceutical Manufacturing:
1-(3-Methoxyphenyl)piperazine hydrochloride is used as an active pharmaceutical ingredient in the development and production of medications targeting mood disorders and related conditions.
Used in Industrial Applications:
1-(3-Methoxyphenyl)piperazine hydrochloride may have other industrial applications, although the specific uses are not detailed in the provided materials. Its stability and solubility as a hydrochloride salt could make it suitable for various industrial processes.

Upstream product

• 110-85-0 piperazine 
• 456-49-5 1-fluoro-3-methoxybenzene 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 536-90-3 m-Anisidine 

Downstream Products

• 95356-13-1 6-<2-<4-(3-methoxyphenyl)-1-piperazinyl>ethyl>-5,6,7,8-tetrahydro-1,6-naphthyridine 
• 142353-32-0 7-Hydroxy-1-{2-[4-(3-methoxy-phenyl)-piperazin-1-yl]-acetylamino}-2,2,6-trimethyl-indan-4-carboxylic acid methyl ester 
• 440117-85-1 C₂₂H₂₅N₃O₃ 
• 83767-49-1 1-(3-chloropropyl)-4-(3-methoxyphenyl)piperazine 
• 16015-71-7 4-(3-methoxyphenyl)piperazine 
• 1385677-94-0 C₁₇H₁₉N₃O₃ 

Relevant academic research and scientific papers

Design, synthesis and anticancer activity of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-1,2,3-thiadiazoles as microtubule-destabilizing agents

Hereby, we report our efforts on discovery and optimization of a new series of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-1,2,3-thiadiazoles as new microtubule-destabilizing agents along our previous study. Guided by docking model analysis, we introduced the 1,2,3-thiadiazole moiety containing the hydrogen-bond acceptors as B-ring of XRP44X analogues. Extensive structure modifications were performed to investigate the detailed structure and activity relationships (SARs). Some compounds exhibited potent antiproliferative activities against three human cancer cell lines (SGC-7901, A549 and HeLa). The compound 5m exhibited the highest potency against the three cancer cell lines. The tubulin polymerization experiments indicated that compound 5m effectively inhibited the tubulin polymerization, and immunostaining assay revealed that it significantly disrupted microtubule dynamics. Moreover, cell cycle studies revealed that compound 5m dramatically arrested cell cycle progression at G2/M phase.

Design, synthesis and evaluation of antiproliferative and antitubulin activities of 5-methyl-4-aryl-3-(4-arylpiperazine-1-carbonyl)-4H-1,2,4-triazoles

A series of novel 5-methyl-4-aryl-3-(4-arylpiperazine-1-carbonyl)-4H-1,2,4-triazoles possessing 1,2,4-triazole as the hydrogen-bond acceptor were designed, synthesized and evaluated for their antiproliferative and tubulin polymerization inhibitory activities. Some of them exhibited moderate activities in vitro against the three cancer cell lines including SGC-7901, A549 and HeLa. Compound 6e exhibited the highest potency against the three cancer cell lines. Moreover, the tubulin polymerization experiments indicated that compound 6e could inhibit the tubulin polymerization. Immunofluorescence study and cell cycle analysis clearly revealed compound 6e could disrupt intracellular microtubule organization, arrest cell cycle at the G2/M phase. In addition, molecular docking analysis demonstrated the interaction of compound 6e at the colchicine-binding site of tubulin. These preliminary results suggested that compound 6e is a new colchicine binding site inhibitor and worthy of further investigation.

Design, synthesis, and biological evaluation of structurally constrained hybrid analogues containing ropinirole moiety as a novel class of potent and selective dopamine D3 receptor ligands

Two series of hybrid analogues were designed, synthesized, and evaluated as a novel class of selective ligands for the dopamine D3 receptor. Binding affinities of target compounds were determined (using the method of radioligand binding assay). Compared to comparator agent BP897, compounds 2a and 2c were found to demonstrate a considerable binding affinity and selectivity for D3 receptor, and especially compound 2h was similarly potent and more selective D3R ligand than BP897, a positive reference. Thus, they may provide valuable information for the discovery and development of highly potent dopamine D3 receptor ligands with outstanding selectivity.

Mechanism and Scope of Base-Controlled Catalyst-Free N-Arylation of Amines with Unactivated Fluorobenzenes

A general method for transition metal-free N-arylation of amines has been developed. Mechanistic studies have revealed that the ability of the base to facilitate the desired amination without promoting unwanted side reactions is the guiding factor. By employing lithium bis(trimethylsilyl)amide as a base the resultant deprotonated amines readily react with a range of unactivated fluorobenzene derivatives. This new arylation method is utilized for the simple two-step synthesis of the antidepressant Vortioxetine.