160237-98-9

Upstream product

• 115857-84-6 (3R,4S)-3-(Benzyloxy)-4-<(S)-2,2-dimethyl-1,3-dioxolan-4-yl>-1-(4-methoxyphenyl)azetidin-2-one 
• 19810-31-2 Benzyloxyacetyl chloride 
• 149818-33-7 (+)-(3R,4S)-cis-3-benzyloxy-4-[(S)-1',2'-dihydroxyethyl]-1-(p-methoxyphenyl)-2-azetidinone 

Downstream Products

• 935668-52-3 (3R,4S)-3-(benzyloxy)-4-ethenyl-2-azetidinone 
• 148968-08-5 (+)-(3R,4R)-1-(p-anisyl)-3-benzyloxy-4-formyl-2-azetidinone 
• 160237-99-0 (3R,4S)-1-(4-methoxyphenyl)-3-(benzyloxy)-4-(hydroxymethyl)-2-azetidinone 
• 160334-80-5 (-)-(3R,4S)-trans-3-benzyloxy-4-formyl-1-(p-methoxyphenyl)-2-azetidinone 
• 614733-25-4 (-)-(3R,4R)-1-(4-methoxyphenyl)-3-benzyloxy-4-hydroxymethyl-2-azetidinone 
• 614733-12-9 (-)-(3R,4S)-3-benzyloxy-4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-azetidinone 
• 614733-26-5 (+)-(3R,4R)-3-benzyloxy-4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-azetidinone 
• 351074-58-3 (+)-(5S,6S)-5-benzyloxy-6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-1,2,5,6-tetrahydro-2-pyridinone 
• 351074-59-4 (+)-(5S,6R)-5-benzyloxy-6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-1,2,5,6-tetrahydro-2-pyridinone 
• 351074-54-9 (2R,3S)-2-benzyloxy-3-[(tert-butyloxycarbonyl)amino]-4-({[tert-butyl(diphenyl)silyl]oxy}methyl)butanal 
• 351074-55-0 (2R,3R)-2-benzyloxy-3-[(tert-butyloxycarbonyl)amino]-4-({[tert-butyl(diphenyl)silyl]oxy}methyl)butanal 
• 351074-51-6 (-)-(3R,4R)-1-(tert-butyloxycarbonyl)-3-benzyloxy-4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-azetidinone 
• 351074-50-5 (+)-(3R,4S)-1-(tert-butyloxycarbonyl)-3-benzyloxy-4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-azetidinone 
• 159612-21-2 (-)-(3R,4R)-1-(4-methoxyphenyl)-3-benzyloxy-4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-azetidinone 

Relevant academic research and scientific papers

Stereoselective synthesis of highly functionalized 5- A nd 6-membered aminocyclitols starting with a readily available 2-azetidinone

Stereoselective transformations of 4-vinyl-2-azetidinone derivative 4 into a variety of highly functionalized 6- A nd 5-membered carbocyclic compounds 7 and 9 were carried out using sequences involving sequential C1-N bond cleavage and Ru-catalyzed ring-closing metathesis. The derived carbocycles were further transformed into polyhydroxylated 6- A nd 5-membered aminocyclitols.

Facile transformation of 3,4-disubstituted 2-azetidinones to chiral 5,6-dihydro-2-pyridones

Chiral 5,6-disubstituted-5,6-dihydro-2(1H)-pyridones were prepared efficiently from readily accessible 3,4-disubstituted-2-azetidinones having preadjusted substituents and stereochemistry through the reductive ring opening of 2-azetidinones followed by Z-selective installation of acetate moiety and re-cyclization to 2-pyridones.

Synthesis and Biological Evaluation of C-3'-Modified Analogs of 9(R)-Dihydrotaxol

Taxol (1) is considered a most exciting new drug in cancer chemotherapy.The promising antitumor activity of 9(R)-dihydrotaxol (3) encouraged us to further explore the structure-activity relationship of this new member of the taxane family.Studies indicate