160238-65-3

Upstream product

• 186581-53-3 diazomethane 
• 160238-64-2 (2R,3S,4R,6S)-3,6-dimethoxy-4-(4-methoxybenzyl)oxy-2-vinyl-3,4,5,6-tetrahydro-2H-pyran 
• 2746-25-0 p-Methoxybenzyl bromide 
• 73541-94-3 methyl 2-deoxy-6-O-(triphenylmethyl)-α-D-arabinohexopyranoside 
• 160238-62-0 methyl 2-deoxy-3-O-(4-methoxybenzyl)-4-O-methyl-α-D-arabino-hexopyranoside 
• 160238-63-1 (2S,3S,4R,6S)-3,6-Dimethoxy-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-carbaldehyde 
• 160238-60-8 (2R,3S,4R,6S)-6-Methoxy-4-(4-methoxy-benzyloxy)-2-trityloxymethyl-tetrahydro-pyran-3-ol 
• 160238-61-9 (2R,3S,4R,6S)-3,6-Dimethoxy-4-(4-methoxy-benzyloxy)-2-trityloxymethyl-tetrahydro-pyran 

Relevant academic research and scientific papers

Total synthesis of (+)-tautomycin

A convergent stereocontrolled total synthesis of (+)-tautomycin (1), a specific inhibitor of protein serine/threonine phosphatases, has been achieved through an esterification of the C1.-C7. fragment A'74 with the C1-C26 fragment B'76 by a modified Yamaguchi method and an aldol reaction of the C17-C26 fragment C 5 with the C1-C16 fragment D 6 using LDA as key steps. The fragments 5 and 6 have been constructed in a stereocontrolled manner, respectively.