160256-56-4

Upstream product

• 120-72-9 indole 
• 102147-52-4 N-benzyloxymethyl-3,4-dibromomaleimide 
• 3587-60-8 Benzyloxymethyl chloride 

Downstream Products

• 480434-36-4 1-[(benzyloxy)methyl]-3-bromo-4-[1-(phenylsulfonyl)-1H-indol-3-yl]-1H-pyrrole-2,5-dione 
• 877610-60-1 3-[1-(benzyloxy)methyl-3-bromo-2,5-dihydro-2,5-dioxopyrrol-4-yl]-1-(1-deoxy-2,3,4,6-tetra-O-benzyl-β-D-glucopyranos-1-yl)-indole 
• 877610-64-5 3-[1-(benzyloxy)methyl-2,5-dihydro-2,5-dioxopyrrol-3-yl]-1-(1-deoxy-2,3,4,6-tetra-O-benzyl-β-D-glucopyranos-1-yl)-1H-indole 
• 877610-62-3 3-[1-(benzyloxy)methyl-2,5-dioxopyrrolidin-3-yl]-1-(1-deoxy-2,3,4,6-tetra-O-benzyl-β-D-glucopyranos-1-yl)-indole 
• 480434-37-5 1-[(benzyloxy)methyl]-3-[1-(phenylsulfonyl)-1H-indol-3-yl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrrole-2,5-dione 
• 480434-46-6 1-[(benzyloxy)methyl]-3-[1H-indol-3-yl]-4-[1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1H-pyrrole-2,5-dione 
• 480434-45-5 1-[(benzyloxy)methyl]-3-[1-(phenylsulfonyl)-1H-indol-3-yl]-4-[1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1H-pyrrole-2,5-dione 
• 160256-37-1 1-<(benzyloxy)methyl>-3,4-dihydro-4-(1H-indol-3-yl)-3-(1-<2-(trimethylsilyl)ethoxymethyl>-1H-indol-3-yl)-1H-pyrrole-2,5-dione 
• 174290-90-5 1-<(benzyloxy)methyl>-3,4-dihydro-4-(<3-<<(benzyloxy)methyl>amino>-3-N,4-O-carbonyl-6-O-(4-methoxybenzyl)-α-D-altropyranosyl>-1H-indol-3-yl)-3-(1-<2-(trimethylsilyl)ethoxymethyl>-1H-indol-3-yl)-1H-pyrrole-2,5-dione 

Relevant academic research and scientific papers

Bisindolylmaleimide derivative, and preparation method and use thereof

The invention provides a bisindolylmaleimide derivative, and a preparation method and a use thereof. The bisindolylmaleimide derivative has a good tumor treatment effect, especially has a good treatment effect on some drug-resistant tumors, and can realize accurate treatment of the drug-resistant tumors.

Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives

Compounds of formula (I): wherein: W1 and W2, together with the carbon atoms to which they are bonded, represent a phenyl group or a pyridyl group, and at least one of the groups W1 or W2 represents a pyridyl group, R1 and R2 each represent a group of formula U-V as defined in the description, X and X1 each represent a hydrogen atom or a hydroxy, alkoxy, mercapto or alkylthio group, Y and Y1 each represent a hydrogen atom, or X and Y, X1 and Y1, together with the carbon atom carrying them, represent a carbonyl or thiocarbonyl group, R4 and R5 are as defined in the description, Q1, Q2 represent a hydrogen atom, or Q1 and Q2, together with the carbon atoms carrying them, form an aromatic bond. Medicaments.

Syntheses and antiproliferative activities of 7-azarebeccamycin analogues bearing one 7-azaindole moiety

Rebeccamycin analogues containing one azaindole unit, with and without a methyl group on the imide nitrogen and with the sugar moiety coupled either to the indole nitrogen or to the azaindole nitrogen were synthesized. To increase the solubility and induc

Staurosporine and ent-staurosporine: The first total syntheses, prospects for a regioselective approach, and activity profiles

The total syntheses of staurosporine and ent-staurosporine have been achieved. Both glycosidic bonds were built from glycal precursors. The first was constructed by intermolecular coupling of an indole anion with a 1,2-anhydrosugar derived from an endo-glycal by direct epoxidation. The second bond was assembled from an exo-glycal by intramolecular iodoglycosylation.