1602577-72-9

Basic information

• Product Name: 5,7-dimethyl-N-(3-(trifluoromethyl)phenylsulfonyl)-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide
• CAS NO: 1602577-72-9
• Molecular Weight: 399.353
• Mol File: 1602577-72-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,7-dimethyl-N-(3-(trifluoromethyl)phenylsulfonyl)-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-dimethyl-N-(3-(trifluoromethyl)phenylsulfonyl)-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide(1602577-72-9)
• EPA Substance Registry System: 5,7-dimethyl-N-(3-(trifluoromethyl)phenylsulfonyl)-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide(1602577-72-9)

Safety Data

• Hazardous Substances Data: 1602577-72-9(Hazardous Substances Data)

Upstream product

• 777-44-6 3-(Trifluoromethyl)benzenesulfonyl chloride 
• 123-54-6 acetylacetone 
• 114040-29-8 ethyl 5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylate 

Relevant articles and documents

Design and synthesis of triazolopyrimidine acylsulfonamides as novel anti-mycobacterial leads acting through inhibition of acetohydroxyacid synthase

Novel triazolopyrimidine acylsulfonamides class of antimycobacterial agents, which are mycobacterial acetohydroxyacid synthase (AHAS) inhibitors were designed by hybridization of known AHAS inhibitors such as sulfonyl urea and triazolopyrimidine sulfonamides. This Letter describes the synthesis and SAR studies of this class of molecules by variation of two parts of the molecule, the phenyl and triazolopyrimidine rings. SAR study describes optimisation of enzyme potency, whole cell potency and evidence of mechanism of action.