1603067-25-9

Basic information

• Product Name: tert-butyl 1‘-(4-methoxybenzyl)-2’-oxospiro[azetidine-3,3‘-indoline]-1-carboxylate
• Synonyms: tert-butyl 1‘-(4-methoxybenzyl)-2’-oxospiro[azetidine-3,3‘-indoline]-1-carboxylate
• CAS NO: 1603067-25-9
• Molecular Weight: 394.47
• Mol File: 1603067-25-9.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl 1‘-(4-methoxybenzyl)-2’-oxospiro[azetidine-3,3‘-indoline]-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 1‘-(4-methoxybenzyl)-2’-oxospiro[azetidine-3,3‘-indoline]-1-carboxylate(1603067-25-9)
• EPA Substance Registry System: tert-butyl 1‘-(4-methoxybenzyl)-2’-oxospiro[azetidine-3,3‘-indoline]-1-carboxylate(1603067-25-9)

Safety Data

• Hazardous Substances Data: 1603067-25-9(Hazardous Substances Data)

Upstream product

• 1603067-24-8 tert-butyl 3-((2-bromophenyl)(4-methoxybenzyl)carbamoyl)azetidine-1-carboxylate 
• 1603067-22-6 tert-butyl 3-((2-bromophenyl)carbamoyl)azetidine-1-carboxylate 
• 142253-55-2 1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid 
• 615-36-1 2-bromoaniline 

Downstream Products

• 1251001-73-6 tert-butyl 2'-oxospiro[azetidine-3,3'-indoline]-1-carboxylate 

Relevant articles and documents

Discovery of 3,3′-Spiro[Azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection

A new series of 3,3′-spirocyclic-2-oxo-indoline derivatives was synthesized and evaluated against respiratory syncytial virus (RSV) in a cell-based assay and animal model. Extensive structure-activity relationship study led to a lead compound 14h, which e

RESPIRATORY SYNCYTIAL VIRUS INHIBITORS

Compounds of Formula (I): wherein W is NR1A or CR1BR1B; Z is N or CH; R1A is C1-C3alkyl, C1-C3haloalkyl C3-C4cycloalkyl or phenyl wherein cycloalkyl or phenyl is optionally mono-, di- or tri-substituted with substituents each independently selected from C1- C3alkyl, halo, amino and C1-C3alkoxy; the two R1B together with the carbon atom to which they are attached combine and form C3-C6cycloalkyl or heterocyclyl, wherein the cycloalkyl is substituent with C(=O)OR1C, NHC(=O)OR1C or NHS(=O)2R1C, and the heterocyclyl is substituent with C(=O)R1C, C(=O)OR1C, S(=O)2 R1C, C(=O)NH2 or C(=O)NR1CR1C'; n is 0, 1 or 2; n, q, R1C, R1C', R2 and R3 are as defined herein, their use as inhibitors of RSV and related aspects.

METHOD FOR PREPARING IMIDAZOLE DERIVATIVE AND INTERMEDIATE THEREOF AND CRYSTAL FORM

Disclosed are a method for preparing an imidazole derivative and crystal form A and crystal form B thereof, and also disclosed is a method for preparing a compound of formula (I) and an intermediate thereof.

RESPIRATORY SYNCYTIAL VIRUS INHIBITORS

Compounds of Formula (I): wherein W is NR1A or CR1BR1B; Z is N or CH, R1A is C1-C3alkyl, C1-C3haloalkyl, C3-C4cycloalkyl or phenyl wherein cycloalkyl or phenyl is optionally mono-, di- or tri-substituted with substituents each independently selected from C1- C3alkyl, halo, amino and C1-C3alkoxy; the two R1B together with the carbon atom to which they are attached combine and form C3- C6cycloalkyl or heterocyclyl, wherein the cycloalkyl is substituent with C(=O)OR1C, NHC(=O)OR1C or NHS(=O)2 R1C, and the heterocyclyl is substituent with C(=O)R1C, C(=O)OR1C, S(=O)2 R1C, C(=O)NH2 or C(=O)NR1CR1C'; q, n, R1C, R2 and R3 are as defined herein, their use as inhibitors of RSV and related aspects.

RESPIRATORY SYNCYTIAL VIRUS INHIBITORS

Compounds of Formula (I): (Formula I), wherein Z1 is NR1A, CHR1A or CR1BR1B; one of Z2 and Z3 is CH or CR1A', the other is N, CH or CR1A'; n is 0, 1 or 2; q is 0, 1 or 2; R1A, R1A', R1B, R2 and R3 are as defined herein, their use as inhibitors of RSV and related aspects.

Imidazole derivative used as antiviral agent and use thereof in preparation of medicament

Disclosed are an antiviral compound and a use thereof in the preparation of a medicament for the treatment of virus infections. Specifically, the present invention relates an imidazole derivative for treating respiratory syncytial virus infection.

SPIRO UREA COMPOUNDS AS RSV ANTIVIRAL COMPOUNDS

The invention concerns novel substituted spiro urea azetidinyl or piperidinyl compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention furth

RSV ANTIVIRAL COMPOUNDS

Inhibitors of RSV replication of formula RI including stereochemically isomeric forms, and salts or solvates thereof, wherein R22, W, Q, V, Z p,s,and Het have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other RSV inhibitors, in RSV therapy.