160350-16-3

Upstream product

• 15356-60-2 (1S,2R,5S)-(+)-menthol 
• 160350-14-1 1-Oxo-2-aza-spiro[4.5]deca-6,9-diene-3-carboxylic acid methyl ester 
• 35356-70-8 Methyl 2-acetamidoacrylate 

Downstream Products

• 331951-77-0 C₄₀H₅₂N₂O₁₀ 
• 331951-76-9 (1R,3S)-1-((E)-3-Benzyloxycarbonylamino-3-methoxycarbonyl-allyl)-2-aza-spiro[4.5]decane-2,3-dicarboxylic acid 2-benzyl ester 3-tert-butyl ester 
• 331951-72-5 (1R,3S)-1-(2-Hydroxy-ethyl)-2-aza-spiro[4.5]decane-2,3-dicarboxylic acid 2-benzyl ester 3-tert-butyl ester 
• 331951-71-4 (1S,3S)-1-(2-Hydroxy-ethyl)-2-aza-spiro[4.5]decane-2,3-dicarboxylic acid 2-benzyl ester 3-tert-butyl ester 
• 331951-70-3 1-allyl-2-aza-spiro[4.5]decane-2,3-dicarboxylic acid 2-benzyl ester 3-tert-butyl ester 
• 331951-75-8 (1R,3S)-1-(2-Oxo-ethyl)-2-aza-spiro[4.5]decane-2,3-dicarboxylic acid 2-benzyl ester 3-tert-butyl ester 
• 331951-69-0 1-oxo-2-aza-spiro[4.5]decane-2,3-dicarboxylic acid 2-benzyl ester 3-tert-butyl ester 
• 160350-17-4 (S)-1-Oxo-2-aza-spiro[4.5]deca-6,9-diene-2,3-dicarboxylic acid 3-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester 2-methyl ester 

Relevant academic research and scientific papers

Concise Synthesis of Arogenate. A Biosynthetic Precursor of Phenylalanine and Tyrosine

A concise new route to arogenate 1 in which Michael addition of the anion derived from methyl 1,4-dihydrobenzoate 2 to the dehydroalanine derivative 3 is the key C-C bond-forming step is described.