160376-84-1

Basic information

• Product Name: 1-(1-broMoethyl)-3,5-bis-trifluoroMethyl-benzene
• Synonyms: 1-(1-broMoethyl)-3,5-bis-trifluoroMethyl-benzene;Benzene, 1-(1-broMoethyl)-3,5-bis(trifluoroMethyl)-;3,5-Bis(trifluoromethyl)-alpha-methylbenzyl bromide
• CAS NO: 160376-84-1
• Molecular Formula: C₁₀H₇BrF₆
• Molecular Weight: 321.0569992
• Mol File: 160376-84-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 181.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.580±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-(1-broMoethyl)-3,5-bis-trifluoroMethyl-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-broMoethyl)-3,5-bis-trifluoroMethyl-benzene(160376-84-1)
• EPA Substance Registry System: 1-(1-broMoethyl)-3,5-bis-trifluoroMethyl-benzene(160376-84-1)

Safety Data

• Hazardous Substances Data: 160376-84-1(Hazardous Substances Data)

Usage

General Description

1-(1-bromomethyl)-3,5-bis-trifluoromethyl-benzene is a chemical compound that consists of a benzene ring with two trifluoromethyl groups at the 3 and 5 positions, and a bromomethyl group at the 1 position. 1-(1-broMoethyl)-3,5-bis-trifluoroMethyl-benzene is used in organic synthesis and as a reagent in various chemical reactions. Its structure and functional groups make it a versatile building block for the synthesis of more complex organic compounds. The bromomethyl group can undergo nucleophilic substitution reactions, while the trifluoromethyl groups can participate in various fluorination and functionalization reactions, making it a useful intermediate in the synthesis of pharmaceuticals and agrochemicals. Overall, 1-(1-bromomethyl)-3,5-bis-trifluoromethyl-benzene is an important compound in organic chemistry with diverse potential applications.

Upstream product

• 68120-60-5 1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol 
• 7789-60-8 phosphorus tribromide 
• 368-63-8 (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol 

Downstream Products

• 1072906-83-2 N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylsulfinyl)ethoxy]pyrimidin-2-amine 
• 1072906-84-3 N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-amine 
• 1057666-91-7 N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl)-5-[2-(methylsulfinyl)ethoxy]pyrimidin-2-amine 
• 1057666-92-8 N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl)-5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-amine 
• 127733-40-8 (S)-α-(3,5-bis(trifluoromethyl)phenyl)ethylamine 
• 1446706-33-7 1-[3,5-bis(trifluoromethyl)phenyl]ethyl azide 
• 1351520-15-4 (R)-1-bromo-1-[3,5-bis(trifluoromethyl)phenyl]ethane 
• 1297609-87-0 (S)-1-bromo-1-[3,5-bis(trifluoromethyl)phenyl]ethane 
• 1072906-82-1 N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine 
• 1057666-90-6 N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine 

Relevant articles and documents

METHOD FOR PRODUCING OPTICALLY ACTIVE 1-BROMO-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANE

A method for preparing optically active 1-bromo-1-[3,5-bis(trifluoromethyl)phenyl]ethane having a high optical purity, which comprises the step of brominating optically active 1-[3,5-bis(trifluoromethyl)phenyl]ethanol by using, as a brominating agent, (a) a combination of a phosphorus halide and hydrogen bromide, (b) a combination of 1,2-dibromo-1,1,2,2-tetrachloroethane and an organic phosphorous compound represented by the general formula (I): P(R1)(R2)(R3) (in the formula, R1, R2, and R3 independently represent a C6-10 aryl group, a C6-10 aryloxy group, a C1-10 alkyl group, a C1-10 alkoxyl group, a C3-6 cycloalkyl group, or a C3-6 cycloalkoxy group), or (c) a combination ofN-bromosuccinimide and a dialkyl sulfide.

NOVEL PYRIMIDINE COMPOUND HAVING DIBENZYLAMINE STRUCTURE AND MEDICAMENT COMPRISING THE SAME

A compound represented by the following general formula (I), wherein R1, R2, R3, R4 and R5 represent hydrogen atom, a halo(lower alkyl) group, cyano group and the like, R6 represents an alk

Zwitterionic tachykinin receptor antagonists

The present invention is directed to certain novel compounds represented by structural formula I: or a pharmaceutically acceptable salt thereof, wherein R3, R5, R6, R7, R8, R11, R12 R13, Q, W, X, Y and Z are defined herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are tachykinin receptor antagonists and are useful in the treatment of psychiatric disorders including depression and anxiety.