1603829-63-5Relevant academic research and scientific papers
A β - chloro - 1, 3 - dithiane derivative of the preparation method
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Paragraph 0014; 0017-0018, (2017/07/01)
The invention relates to a preparation method of a beta-chloro-1,3-dithiane derivative. The preparation method comprises following steps: at the presence of a ferric salt catalyst, substituted styrene, 1,3-dithiane, and N-chlorosuccinimide are dissolved in a solvent, reaction is carried out for 6 to 24h at a temperature ranging from -30 DEG C to the room temperature; and the beta-chloro-1,3-dithiane derivative is obtained via separation and purification. The catalyst used in the preparation method is cheap and easily available; reaction conditions are mild; process is simple; and the beta-chloro-1,3-dithiane derivative can be obtained directly via one-pot reaction. The preparation method possesses significant application potential in medicament synthetic intermediate and natural product synthesis.
Iron-catalyzed radical oxidative coupling reaction of aryl olefins with 1,3-dithiane
Du, Wenbin,Tian, Lixia,Lai, Junshan,Huo, Xing,Xie, Xingang,She, Xuegong,Tang, Shouchu
supporting information, p. 2470 - 2473 (2014/05/20)
An alternative method to an iron-catalyzed radical oxidative cross-coupling reaction followed by 2-chloro-1,3-dithiane and aryl olefins for the synthesis of β-chloro substituent 1,3-dithiane products is presented. The described method has the advantage of mildness of the reaction conditions and tolerates a variety of functional groups. Preliminary mechanistic studies have confirmed the first example of a coupling of 1,3-dithiane with unactivated alkenes that proceeds via an iron-catalyzed oxidative radical intermediate along the reaction pathway.
