1603836-09-4

Basic information

• Product Name: 4S-{(1R,6S,9R)-5-(7-N-benzyl-3-N-(2-cyanoethyl)-3,7-diaza-8-oxa-2-oxobicylo[4,3,0]nonan-9-yl)}-2,3-di-O-tert-butyldimethylsilyl-1-(uracil-1-yl)-β-D-erythro-furanose
• Synonyms: 4S-{(1R,6S,9R)-5-(7-N-benzyl-3-N-(2-cyanoethyl)-3,7-diaza-8-oxa-2-oxobicylo[4,3,0]nonan-9-yl)}-2,3-di-O-tert-butyldimethylsilyl-1-(uracil-1-yl)-β-D-erythro-furanose
• CAS NO: 1603836-09-4
• Molecular Weight: 726.033
• Mol File: 1603836-09-4.mol

Chemical Properties

• CAS DataBase Reference: 4S-{(1R,6S,9R)-5-(7-N-benzyl-3-N-(2-cyanoethyl)-3,7-diaza-8-oxa-2-oxobicylo[4,3,0]nonan-9-yl)}-2,3-di-O-tert-butyldimethylsilyl-1-(uracil-1-yl)-β-D-erythro-furanose(CAS DataBase Reference)
• NIST Chemistry Reference: 4S-{(1R,6S,9R)-5-(7-N-benzyl-3-N-(2-cyanoethyl)-3,7-diaza-8-oxa-2-oxobicylo[4,3,0]nonan-9-yl)}-2,3-di-O-tert-butyldimethylsilyl-1-(uracil-1-yl)-β-D-erythro-furanose(1603836-09-4)
• EPA Substance Registry System: 4S-{(1R,6S,9R)-5-(7-N-benzyl-3-N-(2-cyanoethyl)-3,7-diaza-8-oxa-2-oxobicylo[4,3,0]nonan-9-yl)}-2,3-di-O-tert-butyldimethylsilyl-1-(uracil-1-yl)-β-D-erythro-furanose(1603836-09-4)

Safety Data

• Hazardous Substances Data: 1603836-09-4(Hazardous Substances Data)

Upstream product

• 1603835-99-9 (E)-N-(2-cyanoethyl)-N-(3-hydroxylpropyl)-2,3-di-O-tert-butyldimethylsilyl-5,6-dideoxy-1-(uracil-1yl)-β-D-ribo-5-ene-1-(uracil-1yl)heptofuranuronamide 
• 161867-43-2 (2S,3R,4R,5R)-3,4-bis(tert-butyldimethylsilanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydrofuran-2-carbaldehyde 
• 87418-87-9 2',3'-bis-O-(tert-butyldimethylsilyl)uridine 
• 1603835-79-5 N-2-cyanoethyl-N-3-hydroxylpropyl diethylphosphonoacetamide 
• 34449-95-1 3-(2-cyano-ethyl)-aminopropanol 
• 622-30-0 N-benzyl hydroxylalmine 

Downstream Products

• 1603836-05-0 4S-{(1R,6S,9R)-7-N-benzyl-3,7-diaza-8-oxa-2-oxobicylo[4,3,0]nonan-9-yl}-2,3-di-O-tert-butyldimethylsilyl-1-(uracil-1-yl)-β-D-erythro-furanose 
• 1603836-06-1 4S-{(1S,6R,9S)-7-N-benzyl-3,7-diaza-8-oxa-2-oxobicylo[4,3,0]nonan-9-yl}-2,3-di-O-tert-butyldimethylsilyl-1-(uracil-1-yl)-β-D-erythro-furanose 

Relevant articles and documents

Function-oriented synthesis of liponucleoside antibiotics

Function-oriented synthesis of a class of liponucleoside antibiotics was investigated through rational simplification guided by previous structure-activity relationship studies of caprazamycins and muraymycins to address the issue associated with their molecular complexity. A lactam-fused isoxazolidine scaffold was designed, and a diverse set of lactam-fused isoxazolidines derivatives were constructed by intramolecular 1,3-dipolar cycloaddition of alkenyl nitrones. Several analogues exhibited moderate activity against a range of Gram-positive drug-resistant bacterial pathogens. Caprazamycins and muraymycins are rationally simplified to lactam-fused isoxazolidine derivatives by function-oriented synthesis. The designed compounds are synthesized through a domino reaction including nitrone formation and intramolecular 1,3-dipolar cycloaddition. TBS = tert-butyldimethylsilyl.

Function-oriented synthesis of liponucleoside antibiotics

Function-oriented synthesis of a class of liponucleoside antibiotics was investigated through rational simplification guided by previous structure-activity relationship studies of caprazamycins and muraymycins to address the issue associated with their molecular complexity. A lactam-fused isoxazolidine scaffold was designed, and a diverse set of lactam-fused isoxazolidines derivatives were constructed by intramolecular 1,3-dipolar cycloaddition of alkenyl nitrones. Several analogues exhibited moderate activity against a range of Gram-positive drug-resistant bacterial pathogens.