1603845-40-4

Upstream product

• 163622-50-2 4-amino-5-iodo-7H-pyrrolo[2,3‐d]pyrimidine 
• 1603845-38-0 C₂₄H₂₆N₈O₃ 
• 1603845-37-9 tert-butyl (2-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)carbamate 
• 1603845-36-8 3-(3-nitro-4-phenoxyphenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 1603845-35-7 C₂₇H₂₉N₇O₅ 
• 1603845-34-6 C₂₁H₂₄FN₇O₄ 
• 330793-48-1 4-(4-amino-3-iodopyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester 
• 151266-23-8 4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1603845-39-1 (R)-4-(adamantan-1-yl)-N-(2-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)-2-methylbutanamide 
• 2380-63-4 4-Aminopyrazolo<3,4-d>pyrimidin 

Downstream Products

• 1603845-41-5 C₄₉H₆₆N₈O₆ 
• 1603845-56-2 (R)-4-(1-adamantanyl)-N-(2-(4-(4-amino-3-(4-phenoxy-3-propionamidophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)-2-methylbutanamide 

Relevant academic research and scientific papers

Development of small molecules targeting the pseudokinase Her3

Abstract Her3 is a member of the human epidermal growth factor receptor (EGFR) tyrosine kinase family, and it is often either overexpressed or deregulated in many types of human cancer. Her3 has not been the subject of small-molecule inhibitor development

HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION

Provided are bifunctional small molecules of Formula (I): or pharmaceutically acceptable salts thereof, wherein M represents a small organic molecule which binds, covalently or non-covalently, a kinase, such as Her3 protein kinase; L1 represents a linker; and RH represents a hydrophobic group. An example of a compound of Formula (I) is a compound of Formula (II): Also provided are pharmaceutical compositions comprising a compound of Formula (I) or (II) and methods of using such compounds for treating proliferative diseases.