1603850-73-2Relevant academic research and scientific papers
A new chemical approach to human ABO Histo-Blood group Type 2 antigens
Hara, Atsushi,Imamura, Akihiro,Ando, Hiromune,Ishida, Hideharu,Kiso, Makoto
, p. 414 - 437 (2014)
A new chemical approach to synthesizing human ABO histo-blood type 2 antigenic determinants was developed. N-Phthaloyl-protected lactosaminyl thioglycoside derived from lactulose via the Heyns rearrangement was employed to obtain a type 2 core disaccharide. Use of this scheme lowered the overall number of reaction steps. Stereoselective construction of the a-galactosaminide/galactoside found in A- and B-Antigens, respectively, was achieved by using a unique di-tert-butylsilylene-directed a-glycosylation method. The proposed synthetic scheme provides an alternative to existing procedures for preparing ABO blood group antigens.
