1603897-67-1

Upstream product

• 1603907-36-3 4-(1-(2-(2, 6-difluorophenyl)acetyl)piperidin-4-yl)-2-methylpyrimidine-5-carboxylic acid 
• 78710-55-1 3,5-dimethylbenzyl amine 
• 85068-28-6 2,6-difluorophenylacetic acid 
• 1603911-33-6 ethyl 4-(1-(2-(2, 6-difluorophenyl)acetyl)piperidin-4-yl)-2-methylpyrimidine-5-carboxylate 

Downstream Products

• 1603899-71-3 4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-N-(3,5-dimethylbenzyl)-N,2-dimethylpyrimidine-5-carboxamide 

Relevant academic research and scientific papers

RORY MODULATORS

Described are RORy modulators of the formula (I), and N-oxides thereof, and pharmaceutically acceptable salts thereof, and solvates and hydrates thereof, wherein R1, R2, R3, R4, R5, R6, Ra, x, y, L, G, Z, the bond denoted by q , the ring system denoted by A and the ring system denoted by B are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORy activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORy activity, for example, autoimmune and/or inflammatory disorders.