1603898-81-2

Upstream product

• 1603898-68-5 N,N-diethyl-O-([1-(3-methoxyphenyl)-3-(triethylsilyl)]naphth-2-yl)-carbamate 
• 1603898-34-5 N,N-diethyl-O-((1-iodo-3-(triethylsilyl))naphth-2-yl)-carbamate 
• 61912-14-9 2-naphthyl diethylcarbamate 

Relevant academic research and scientific papers

Directed ortho metalation strategies. Effective regioselective routes to 1,2-, 2,3-, and 1,2,3-substituted naphthalenes

The regioselective synthesis of 2,3-di- and 1,2,3-trisubstituted naphthalenes via Directed ortho Metalation (DoM) strategies of N,N-diethyl-O-naphthyl-2-carbamate (1) is presented. Sequential LiTMP metalation-electrophile quench and s-BuLi/TMEDA (or t-BuLi)-electrophile quench of naphthyl-2-carbamate 1 provides a general route to contiguously substituted naphthalenes (6) with full regioselectivity. Further derivatization via ipso-halodesilylation and Suzuki-Miyaura cross-coupling leads ultimately to substituted halonaphthalenes and benzonaphthopyranones (9).