1604040-72-3Relevant academic research and scientific papers
Highly regio-and enantioselective synthesis of polysubstituted 2 H -pyrroles via pd-catalyzed intermolecular asymmetric allylic dearomatization of pyrroles
Zhuo, Chun-Xiang,Zhou, Yong,You, Shu-Li
supporting information, p. 6590 - 6593 (2014/05/20)
A highly efficient synthesis of chiral polysubstituted 2H-pyrrole derivatives via a Pd-catalyzed intermolecular asymmetric allylic dearomatization reaction of pyrroles is presented. With the commercially available palladium precursor and chiral ligand, the polysubstituted 2H-pyrrole products containing a chiral quaternary carbon center were obtained with up to 97% ee and >95/5 regioselectivity.
