160410-56-0Relevant articles and documents
Convenient Synthesis of O-(2-Acetamido-2-deoxy-β-D-glucopyranosyl)-serine and -threonine Building Blocks for Solid-phase Glycopeptide Assembly
Vargas-Berenguel, Antonio,Meldal, Morten,Paulsen, Hans,Bock, Klaus
, p. 2615 - 2620 (2007/10/02)
The suitably protected building blocks for solid-phase glycopeptide synthesis, Nα-Fmoc-Ser(Ac3-β-D-GlcNAc)-OPfp, 11, and Nα-Fmoc-Thr(Ac3-β-D-GlcNAc)-OPfp, 12, have been synthesized by stereoselective glycosidation of the 2-allyloxycarbonylamino glycosyl donor 7 with Nα-Fmoc-Ser-OPfp, 3, and Nα-Fmoc-Thr-OPfp, 4, followed by Pd0-catalysed allyl transfer from the N-allyloxycarbonyl group in the presence of acetic anhydride.