1604440-58-5Relevant articles and documents
Synthesis of oxidative metabolites of K-115, a novel Rho-kinase inhibitor
Gomi, Noriaki,Shibuya, Kimiyuki,Kawamura, Kiyoshi,Kabeya, Mototsugu
, (2022/02/01)
In humans, oxidative metabolites 2–4 of (S)-4-fluoro-5-(2-methyl-1,4-diazepan-1-ylsulfonyl)-isoquinoline hydrochloride dihydrate (K-115, 1), a novel Rho-kinase inhibitor, are mainly formed by aldehyde oxidase and CYP3A4 / 3A5 in human liver S9 and hepatoc
Tetrahydroimidazo(1,5-D)[1,4]Oxazepine Derivative
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Paragraph 0199; 0200; 0201, (2014/09/03)
A compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof works as an mGluR2 antagonist, and is applicable as a therapeutic agent for neurological disorders related to glutamate dysfunction and diseases involving th