1604677-07-7Relevant academic research and scientific papers
A spiro oxidation indol butene acid lactone the synthetic method of the compound of
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Paragraph 0030; 0031; 0032, (2016/10/07)
The invention relates to the technical field of organic chemistry and particularly relates to a synthesis method for a spirally-epoxidized indole butenolide compound which is shown as the formula IV. The method comprises takes alkynal shown as the formula
Cooperative N-heterocyclic carbene (NHC)-Lewis acid-mediated regioselective umpolung formal [3 + 2] annulations of alkynyl aldehydes with isatins
Zhang, Yu,Lu, Yingyan,Tang, Weifang,Lu, Tao,Du, Ding
, p. 3009 - 3015 (2014/05/06)
A novel and regioselective umpolung synthesis of spirooxindoles has been developed by cooperative NHC-Lewis acid-mediated formal [3 + 2] annulations of alkynyl aldehydes with isatins. In most cases, the reactions proceeded via a3-d3 umpolung of alkynyl aldehydes resulting in spirooxindole butenolides. In a few cases, spirooxindole furan-3(2H)-ones were formed as the major products via an a1-d1 umpolung process by controlling the reaction temperature. These newly formed spirooxindoles could provide promising candidates for chemical biology and drug lead discovery.
