1604818-92-9

Upstream product

• 573-11-5 2,3,4-Trimethoxy-benzoic acid 
• 56124-67-5 1,3-dihydroxy-5,6-dimethoxy-9H-xanthen-9-one 
• 1604818-83-8 1-hydroxy-5,6-dimethoxy-3-(3'-methylbut-2'-enyloxy)-9H-xanthen-9-one 
• 1604818-84-9 1,5,6-trimethoxy-3-(3'-methylbut-2'-enyloxy)-9H-xanthen-9-one 
• 1604818-88-3 1,5,6-trimethoxy-4-(2'-methylbut-3'-en-2'-yl)-9-oxo-9H-xanthen-3-yl acetate 
• 1604818-89-4 3-hydroxy-1,5,6-trimethoxy-4-(2'-methylbut-3'-en-2'-yl)-9H-xanthen-9-one 
• 1604818-90-7 3-(benzyloxy)-1,5,6-trimethoxy-4-(2'-methylbut-3'-en-2'-yl)-9H-xanthen-9-one 
• 1604818-91-8 3-(benzyloxy)-4-(4'-hydroxy-2'-methylbutan-2'-yl)-1,5,6-trimethoxy-9H-xanthen-9-one 
• 2103-57-3 2,3,4-trimethoxybenzaldehyde 

Downstream Products

• 1604818-93-0 3-(benzyloxy)-1,5,6-trimethoxy-4-(2'-methyl-4'-carboxy-2-yl)-9H-xanthen-9-one 
• 1604818-95-2 6-benzyloxy-1,5,-dihydroxy-4',4'-dimethyl-4,5-dihydropyr-6'-one[2',3':3,4]xanthone 
• 1604818-96-3 6-benzyloxy-1,-hydroxy-5-methoxy-4',4'-dimethyl-4,5-dihydropyr-6'-one[2',3':3,4]xanthone 

Relevant academic research and scientific papers

Total synthesis and RXRα-mediated transcription studies of neriifolone B and related compounds

Neriifolone B (1), a natural product containing a novel 4′,4′-dimethyl-4′,5′-dihydropyran-6-one[2′, 3′:3,4]xanthone skeleton, was found to be a potent inhibitor of transcription mediated by retinoid X receptor α (RXRα). The first total synthesis of neriifolone B (1) was achieved in 14 steps with an overall yield of 7.1%. A Claisen rearrangement was employed as the key step in the sequence. The activity of six natural xanthones and eight compounds related to neriifolone B (1) against RXRα-mediated transcription was evaluated. Two neriifolone B analogs, 17 and 11″, were potent inhibitors of RXRα transcriptional activity. Preliminary structure-activity relationship studies are discussed briefly.