1605-54-5

Basic information

• Product Name: methyl[bis(trifluoromethyl)]phosphane
• Synonyms: Methyl[bis(trifluoromethyl)]phosphine; phosphine, methylbis(trifluoromethyl)-
• CAS NO: 1605-54-5
• Molecular Formula: C₃H₃F₆P
• Molecular Weight: 184.0201
• Mol File: 1605-54-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 28.6°C at 760 mmHg
• Vapor Pressure: 668mmHg at 25°C
• CAS DataBase Reference: methyl[bis(trifluoromethyl)]phosphane(CAS DataBase Reference)
• NIST Chemistry Reference: methyl[bis(trifluoromethyl)]phosphane(1605-54-5)
• EPA Substance Registry System: methyl[bis(trifluoromethyl)]phosphane(1605-54-5)

Safety Data

• Hazardous Substances Data: 1605-54-5(Hazardous Substances Data)

Upstream product

• 115-10-6 Dimethyl ether 
• 460-96-8 bis(trifluoromethyl)phosphine 
• 359-64-8 iodo-bis-trifluoromethyl-phosphine 
• 544-97-8 dimethyl zinc(II) 
• 19287-45-7 diborane 
• 867-46-9 (methoxy)dichloroborane 
• 53716-32-8 Bis(trifluormethyl)phosphanylsilan 
• 121-43-7 Trimethyl borate 
• 650-52-2 bis(trifluoromethyl)chlorophosphine 
• 432-04-2 tris(trifluoromethyl)phosphine 
• 74-88-4 methyl iodide 
• 917-54-4 methyllithium 
• 676-83-5 methyldichlorophosphane 
• 75-63-8 Bromotrifluoromethane 

Downstream Products

• 2314-97-8 iodotrifluoromethane 
• 421-57-8 dimethyl(trifluoromethyl)phosphine 
• 36386-20-6 (CO)3NiP(CF₃)2CH₃ 

Relevant articles and documents

P-bis(trifluoromethyl) ylides: Synthesis and reactions

The methylation of bis(trifluoromethyl)phosphines by MeOSO2CF3, yielding the respective phosphonium salts was described. Methylation was done using methyl triflate at 100 °C without a solvent. It was found that deprotonation using MeN = P(NEt2)3 led to the phosphorus ylides stable in solution at ambient temperatures, which could be converted into 1,2λ5σ5-oxphosphetanes by adding hexafluoroacetone.

The new compound silylbis(trifluoromethyl)phosphine and some phosphorus-silicon bond cleavage reactions

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Advances in trifluoromethylating phosphorus compounds

The System CF3IMe3P is re-investigated and Me2PCF3, Me4P+I-, (CF3)2PMe3, Me3PI2, [Me3(CF3)P]+I- are found as products. Using CF3Br/P(NEt2)3 the phosphines R12PCF3 and R1P(CF3)2 (e.g. R1 = Me, iPr, NEt2) can be obtained which are precursors either for phosphoranes (e.g. 1,2λ5σ5-oxaphosphetanes) or phosphonium salts (e.g. [R12(Me)PCF3]+X- or [R1(Me)P(CF3)2X-]. The latter are deprotonated to furnish methylene phosphoranes R12(CH2=)PCF3 or R1(CH2=)P(CF3)2, reactive synthons. From CF3Br/ P(NEt2)3/P(OPh)3 the phosphine P(CF3)3 is available, which turned out to be a potent electrophile. Amido phospites ROP(NEt2)2 and halides R2X (R2= CCl2CF3, X= Cl; R2= CF=CFCF3, X= F; R2= C6F5, X= Br, I; R2= C(CF3)3, X= Br; R2= SCF3, X= CF3) undergo an ARBUZOV reaction.