1605-68-1 Usage
Description
Taxane is a microtubule-binding chemotherapeutic agent derived from the phloem (inner bark) of the Pacific yew, Taxus brevifolia. It plays a crucial role in the treatment of various types of cancer due to its ability to stabilize microtubules and inhibit cell division.
Uses
Used in Anticancer Applications:
Taxane is used as an anticancer agent for its ability to bind to microtubules, which helps in stabilizing them and inhibiting cell division. This action leads to the prevention of cancer cell growth and proliferation, making it effective against a range of malignancies.
Used in Pharmaceutical Industry:
Taxane is used as a key component in the development of cancer drugs, such as paclitaxel and docetaxel. These drugs have been widely utilized in the treatment of various cancers, including breast, ovarian, lung, and prostate cancer, due to their potent anti-cancer properties.
Used in Drug Delivery Systems:
In order to enhance the efficacy and bioavailability of taxane-based drugs, researchers have developed novel drug delivery systems. These systems, which may include liposomes, nanoparticles, or polymeric carriers, aim to improve the targeted delivery of taxane to cancer cells, reduce side effects, and increase the overall therapeutic outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 1605-68-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,0 and 5 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1605-68:
(6*1)+(5*6)+(4*0)+(3*5)+(2*6)+(1*8)=71
71 % 10 = 1
So 1605-68-1 is a valid CAS Registry Number.
InChI:InChI=1/C20H36/c1-14-7-6-11-20(5)12-10-17-15(2)8-9-16(13-18(14)20)19(17,3)4/h14-18H,6-13H2,1-5H3
1605-68-1Relevant articles and documents
Process for mass production of GMP paclitaxel and related taxanes
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, (2008/06/13)
A process for the purification of paclitaxel and/or cephalomannine and/or 10-DAB III and/or 9-DHAB III is described. A series of extractions, separations, and purifications provides these products in commercial quantities with high purity. The source for these natural products is from readily available renewable biomaterials, such as leaves and stems from the yew, T. canadensis.
Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
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, (2008/06/13)
The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) STR1 with β-lac
Method for the isolation and purification of taxol and its natural analogues
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, (2008/06/13)
An improved method for isolating taxol and certain clinically important analogues of taxol from a crude extract of a naturally occuring Taxus species comprising treating the extract by reverse phase liquid chromatography on an adsorbent, causing the taxol and the taxol analogues to be absorbed on the adsorbent, and recovering taxol and the natural analogues of taxol from the adsorbent by elution with an elutant. The compounds thus isolated in pure form are taxol, taxol-7- xyloside, 10-deacetyltaxol, 10-deacetyltaxol-7-xyloside, cephalomannine, cephalomannine-7-xyloside, 10-deacetylcephalomannine-7-xyloside, baccatin III, 10-deacetylbaccatin III, baccatin VI, brevitaxane A, and taxiflorine.