160510-67-8Relevant articles and documents
Isomeric platinum organometallics derived from pyrimidine, pyridazine or pyrazine and their potential as antitumor drugs
Singh, Khushwant,Jana, Achintya,Lippmann, Petra,Ott, Ingo,Das, Neeladri
, p. 112 - 117 (2019)
Two new organometallic compounds (1 and 2) containing multiple platinum(II) centers have been synthesized. 1 and 2 are structural isomers having the same molecular formula but they are different either in terms of the N-heterocycle present in the center or relative orientation of the two pendant arms bearing the alkynyl-Pt(PEt3)2I units. 1 and 2 have been characterized using FTIR, NMR, HRMS and elemental analyses, besides structural characterization of one of the complex (1) using single crystal XRD. The cytotoxic potential of 1 and 2 and a previously reported di-PtII organometallic molecule (3) have been studied against four cancer cell lines – HT-29 (colon carcinoma), MCF-7, MDA-MB-231 (breast cancer) and SK-HEP-1 (human hepatic adenocarcinoma). Comparison of IC50 values suggests that these Pt(II) based organometallic compounds have antiproliferative activity that is comparable with that of cisplatin.
Self-assembly of 3,6-bis(4-triazolyl)pyridazine ligands with copper(I) and silver(I) ions: Time-dependant 2D-NOESY and ultracentrifuge measurements
Happ, Bobby,Pavlov, Georges M.,Altuntas, Esra,Friebe, Christian,Hager, Martin D.,Winter, Andreas,Goerls, Helmar,Guenther, Wolfgang,Schubert, Ulrich S.
experimental part, p. 873 - 880 (2011/10/08)
Two 3,6-bis(R-1H-1,2,3-triazol-4-yl)pyridazines (R=mesityl, monodisperse (CH2-CH2O)12CH3) were synthesized by the copper(I)-catalyzed azide-alkyne cycloaddition and self-assembled with tetrakis(acetonitrile)copp
Oligomers containing ethynylpyridazine moieties: Synthesis, fluorescence and liquid crystalline properties. Diazines 50
Achelle, Sylvain,Ple, Nelly,Kreher, David,Mathevet, Fabrice,Turck, Alain,Attias, Andre-Jean
, p. 357 - 374 (2008/09/20)
Conjugated oligomers with ethynylpyridazine units have been synthetized by Sonogashira and Suzuki cross-coupling reactions. Some of them present interesting liquid crystals properties investigated by differential scanning calorimetry (DSC) and polarized l